Drug Delivery Technology Development in Canada

Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve rational site-targeting, or facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of the presence of the drug in the body.

Drug delivery is often approached through a drug’s chemical formulation, medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form development and selection of route of administration; the latter sometimes even being considered part of the definition. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and adherence. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed stemming from the inventions conceived and developed within academic institutions. Many have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases.

This Special Issue serves to highlight the progress of drug delivery within Canada. We invited articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.

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Book Information: Kishor M. Wasan, Ildiko Badea; Pages: 352; Published: December 2019, (This book is a printed edition of the Special Issue Drug Delivery Technology Development in Canada that was published in Pharmaceutics)

Ellen K. Wasan, Jinying Zhao, Joshua Poteet, Munawar A. Mohammed, Jaweria Syeda,
Kevin Soulsbury, Jacqueline Cawthray, Amanda Bunyamin, Chi Zhang, Brian M. Fahlman
and Ed S. Krol
Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of
Raynaud Phenomenon and Chilblains
Reprinted from: Pharmaceutics 2019, 11, 594, doi:10.3390/pharmaceutics11110594 ……… 5

Babu V. Sajesh, Ngoc H. On, Refaat Omar, Samaa Alrushaid, Brian M. Kopec,
Wei-Guang Wang, Han-Dong Sun, Ryan Lillico, Ted M. Lakowski, Teruna J. Siahaan,
Neal M. Davies, Pema-Tenzin Puno, Magimairajan Issai Vanan and Donald W. Miller
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier
for the Treatment of Brain Tumors
Reprinted from: Pharmaceutics 2019, 11, 481, doi:10.3390/pharmaceutics11090481 ……… 23

Waleed Mohammed-Saeid, Abdalla H Karoyo, Ronald E Verrall, Lee D Wilson and
Ildiko Badea
Inclusion Complexes of Melphalan with Gemini-Conjugated β-Cyclodextrin: Physicochemical
Properties and Chemotherapeutic Efficacy in In-Vitro Tumor Models
Reprinted from: Pharmaceutics 2019, 11, 427, doi:10.3390/pharmaceutics11090427 ……… 39

David Fortin
Drug Delivery Technology to the CNS in the Treatment of Brain Tumors:
The Sherbrooke Experience
Reprinted from: Pharmaceutics 2019, 11, 248, doi:10.3390/pharmaceutics11050248 ……… 54

Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide

Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles

The effect of material properties and process parameters on die filling at varying throughputs: A pls-model-based analysis

Asmita Poudel, George Gachumi, Kishor M. Wasan, Zafer Dallal Bashi, Anas El-Aneed and
Ildiko Badea
Development and Characterization of Liposomal Formulations Containing Phytosterols
Extracted from Canola Oil Deodorizer Distillate along with Tocopherols as Food Additives
Reprinted from: Pharmaceutics 2019, 11, 185, doi:10.3390/pharmaceutics11040185 ……… 70

Jiahao Huang, Peter X. Chen, Michael A. Rogers and Shawn D. Wettig
Investigating the Phospholipid Effect on the Bioaccessibility of Rosmarinic Acid-Phospholipid
Complex through a Dynamic Gastrointestinal in Vitro Model
Reprinted from: Pharmaceutics 2019, 11, 156, doi:10.3390/pharmaceutics11040156 ……… 86

Kevin J. H. Allen, Rubin Jiao, Mackenzie E. Malo, Connor Frank and Ekaterina Dadachova
Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating
Antibody Pharmacokinetics
Reprinted from: Pharmaceutics 2018, 10, 262, doi:10.3390/pharmaceutics10040262 ……… 104

Hoda Soleymani Abyaneh, Amir Hassan Soleimani, Mohammad Reza Vakili, Rania Soudy,
Kamaljit Kaur, Francesco Cuda, Ali Tavassoli and Afsaneh Lavasanifar
Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect
of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance
Reprinted from: Pharmaceutics 2018, 10, 196, doi:10.3390/pharmaceutics10040196 ……… 112

Zaid H. Maayah, Ti Zhang, Marcus Laird Forrest, Samaa Alrushaid, Michael R. Doschak,
Neal M. Davies and Ayman O. S. El-Kadi
DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell
Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways
Reprinted from: Pharmaceutics 2018, 10, 144, doi:10.3390/pharmaceutics10030144 ……… 130

Griffin Pauli, Wei-Lun Tang and Shyh-Dar Li
Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT)
for Liposomal Loading of Poorly Water-Soluble Compounds
Reprinted from: Pharmaceutics 2019, 11, 465, doi:10.3390/pharmaceutics11090465 ……… 146

Farinaz Ketabat, Meenakshi Pundir, Fatemeh Mohabatpour, Liubov Lobanova,
Sotirios Koutsopoulos, Lubomir Hadjiiski, Xiongbiao Chen, Petros Papagerakis and
Silvana Papagerakis
Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and
Future Perspectives
Reprinted from: Pharmaceutics 2019, 11, 302, doi:10.3390/pharmaceutics11070302 ……… 158

Mahdi Roohnikan, Elise Laszlo, Samuel Babity and Davide Brambilla
A Snapshot of Transdermal and Topical Drug Delivery Research in Canada
Reprinted from: Pharmaceutics 2019, 11, 256, doi:10.3390/pharmaceutics11060256 ……… 187

Esen Sokullu, Hoda Soleymani Abyaneh and Marc A. Gauthier
Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics
Reprinted from: Pharmaceutics 2019, 11, 211, doi:10.3390/pharmaceutics11050211 ……… 202

Bahman Homayun, Xueting Lin and Hyo-Jick Choi
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Reprinted from: Pharmaceutics 2019, 11, 129, doi:10.3390/pharmaceutics11030129 ……… 240

Courtney van Ballegooie, Alice Man, Mi Win and Donald T. Yapp
Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy
Reprinted from: Pharmaceutics 2019, 11, 125, doi:10.3390/pharmaceutics11030125 ……… 269

Ada W.Y. Leung, Carolyn Amador, Lin Chuan Wang, Urmi V. Mody and Marcel B. Bally
What Drives Innovation: The Canadian Touch on Liposomal Therapeutics
Reprinted from: Pharmaceutics 2019, 11, 124, doi:10.3390/pharmaceutics11030124 ……… 301

Grace Cuddihy, Ellen K. Wasan, Yunyun Di and Kishor M. Wasan
The Development of Oral Amphotericin B to Treat Systemic Fungal and Parasitic Infections:
Has the Myth Been Finally Realized?
Reprinted from: Pharmaceutics 2019, 11, 99, doi:10.3390/pharmaceutics11030099 ………. 327

excipients

Drug Delivery Technology Development in Canada

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