Self-Generating nano-emulsifying technology for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and miscellaneous drugs
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of a hydrophobic or poorly-water soluble drug. The methodology for SNEDDS preparation has been established on a number of therapeutic agents from several pharmacological classes.
The requisite studies have validated the concept, and detailed experimentations in pharmaceutical, pharmacokinetics, and pharmacodynamics evaluations have corroborated the feasibility of SNEDDS formulation in providing higher levels of drug uploading, transport, dissolution, and intestinal permeation together with enhanced bioavailability at the site, and enhanced therapeutic effectiveness of the drug administered through oral route. The anti-cancer and anti-diabetic drugs having solubility issues, poor absorption, unwanted toxicity, and low bioavailability at the site of action have been dealt-with by the SNEDDS technology.
The present review encompasses the SNEDDS technology applications primarily in these segments of drugs, and natural bioactive agents as well as synthetic agents for several bioactivities. It analyses the SNEDDS formulation approaches both in liquid and solid-SNEDDS based formulations, the absorption differences, bioavailability, and overall therapeutic effectiveness of these SNEDDS based products in comparison to the free drug behavior and other forms of drug delivery modalities as well as administration routes.
Article Information: Naseem Akhtar, Riaz A. Khan, Salman A. A. Mohammad, Mohammad Yusuf, Varsha Singh, Hamdoon A .A. Mohammad, Mohsen S. Alomar, Ahmed Abdellatif, Mamuna Naz, Habib Khadri; Journal of Drug Delivery Science and Technology, 2020.
Keywords: Self-nanoemulsifying system, Anti-cancer, Anti-diabetic, Cardioprotective, Ant-hypertensive, Natural products, Lipids formulation, Bioavailability.