Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications
![Historic evolution of the number of available formulations. (a) Combined DrugBank and Pillbox data track the number of different formulations of the same APIs available to patients over time, ranked by number of formulations available in 2019. (b) Average number of available formulations per API. (c) Correlations of the number of formulations available for the 300 most prescribed medications of 2019.](https://www.pharmaexcipients.com/wp-content/uploads/2020/11/Historical-Evolution-and-Provider-Awareness-of-Inactive-Ingredients-in-Oral-Medications.png)
Purpose: A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare professionals consider the inactive ingredient portion when prescribing medications to patients.
Methods: We used data mining to track the number of available formulations for the same medication over time and correlate the number of available versions in 2019 to the numberof manufacturers, the years since first approval, and the number of prescriptions. A focused survey among healthcare professionals was conducted to query their consideration of the inactive ingredient portion of a medication when writing prescriptions.
Results: The number of available versions of a single medication have dramatically increased in the last 40 years. The number of available, different versions of medications are largely determined by the number of manufacturers producing this medication. Healthcare providers commonly do not consider the inactive ingredient portion when prescribing a medication.
Conclusions: A multitude of available versions of the same medications provides a potentially under-recognized opportunity to prescribe the most suitable formulation to a patient as a step towards personalized medicine and mitigate potential adverse events from inactive ingredients.
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Article Information: Reker, D., Blum, S.M., Wade, P. et al. Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications. Pharm Res 37, 234 (2020). https://doi.org/10.1007/s11095-020-02953-2