Process Monitoring and Control of Drug Fluidized Bed Granulation and Its New Application

Nowadays, fluidized bed granulation is a widely used technique in the pharmaceutical industry. Several factors, including process settings, powder qualities, and binder properties, impact its performance. The monitoring of the fluidized bed granulation process is a complex process. This paper describes the fluidized bed granulation process’s real-time online feedback control method. The focus of this study is on a Process analysis technology (PAT) based feedback control system for batch processing monitoring of fluidized bed granulation operations. It promotes the advancement of fluidized bed granulation technology from laboratory to mass production, giving a more efficient and cost-effective monitoring method for the pharmaceutical industry, based on the PAT process. In addition, fluid bed-based granulation produces particles with lower density and more porous structure, thus improving the water solubility of drugs.

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Yaoyao Wang
Process Monitoring and Control of Drug Fluidized Bed Granulation and Its New Application Advances in Social Science, Education and Humanities Research, volume 666
Proceedings of the 2022 International Conference on Science and Technology Ethics and Human Future (STEHF 2022)