Development and exploration on flowability of solid self-nanoemulsifying drug delivery system of morin hydrate
Morin hydrate (MH) is a promising flavonoid with diverse biological activities; unfortunately, it finds limited clinical application due to its low water solubility. Herein, we developed a liquid self nano-emulsifying drug delivery system (l-SNEDDS) employing Labrafil M 1944 CS, Cremophor RH 40, and Transcutol HP. The l-SNEDDS has been solidified by physical adsorption using inert carriers, i.e., Neusilin US2 and Aerosil 200. The S-SNEDDS was thoroughly investigated for flow function (FF), effective angle of wall friction (EAWF), and effective angle of internal friction (EAIF) employing a powder flow tester (PFT). The solid-state characterizations of S-SNEDDS were performed using FTIR, DSC, PXRD, and SEM. Further, in vitro dissolution, in vivo pharmacokinetic, and shelf life estimation were performed on selected SOF-2 formulation.
Highlights
- • Solid SNEDDS of MH was prepared by physical adsorption method.
- • Flowability of solid SNEDDS was investigated by powder flow tester.
- • Solid state characterization confers transformation of crystalline to amorphous.
- • In vitro-In vivo studies revealed an improvement of dissolution & bioavailability.
- • The estimated shelf life of solid SNEDDS of MH was found to be 27.57 months.
The SOF-2 reveals good emulsifying ability, particle size (52 ± 4.25 nm), and PDI (0.133 ± 0.06). The FF and Jenike’s classification suggests the “free-flowing” nature of S-SNEDDS prepared using Neusilin US2. Further, S-SNEDDS prepared using Neusilin US2 showed a low friction angle, i.e., EAWF and EAIF, than Aerosil 200, therefore, a better flowability. The solid-state characterization of SOF-2 demonstrated the transition of MH from crystalline to amorphous state and good compatibility between MH and Neusilin US2. Further, SOF-2 showed more dissolution than pure MH and subsequently 2.97-fold increments in its oral bioavailability. Moreover, the shelf life of SOF-2 was reported to be 27.57 months, suggesting its excellent physical and chemical stability. In brief, solidifying l-SNEDDS and investigating flow behaviors by PFT could find attention in the pharmaceutical and food industry for commercial purposes.
Pankaj V. Dangre, Shital B. Shinde, Sanjay J. Surana, Pankaj G. Jain, Shailesh S. Chalikwar,
Development and exploration on flowability of solid self-nanoemulsifying drug delivery system of morin hydrate,
Advanced Powder Technology,
Volume 33, Issue 8, 2022, 103716, ISSN 0921-8831,
https://doi.org/10.1016/j.apt.2022.103716.