New and Novel Excipients
The pharmaceutical industry needs innovative, new and novel excipients solutions to support the developments in next generation therapeutics, new manufacturing concepts (eg. continuous manufacturing, 3Dprinting, etc.), drug delivery and API challenges such as solubility and permeability just to mention some. In preparation of the upcoming CPhI Worldwide in Frankfurt I am looking at the news and found information on two new excipients which I like to share this week Klucel™ xtend and BioSustane™ – I hope to find some more to share with you.
The presented content is just small intro based on the companies information. Links are provided to the product sites and webinars on the topic.
klucel™ xtend HPC – new hydrophilic matrix polymer addresses the limitations of traditional hypromellose polymers
Ashland introduces Klucel™ xtend hydroxypropyl cellulose (HPC) controlled release matrix former, designed to deliver unsurpassed process versatility and release profile efficiency.
Until now, there were limited options for managing the release profile of formulations, especially high dose, controlled release formulations. Ashland’s step change Klucel™ xtend HPC has been shown to match the release profile of widely used hypromellose controlled release formulations at half the polymer concentration.
The need for hot-melt extrusion (HME) polymers is expected to grow as the pharma industry moves to implement more continuous and sustainable processes. klucel™ xtend HPC is the only cellulosic excipient that provides a compendial extended-release polymer option for plasticizer-free HME. This oral matrix former is the new gold standard for extended-release tablets. klucel™ xtend HPC extending your options for
- highly soluble APIs
- high drug load formulations
- melt granulation or HME processing
- increased patient compliance
- complex formulations
Webinar with Kapish Karan October 11, 2022 – join here
More product information – click here
Eastman BioSustane™
A solution for poor solubility, extended release, depot formulation, and abuse deterrence
Eastman BioSustane™ SAIB NF is a novel, non-polymeric excipient derived from biobased material: sucrose. Highly hydrophobic, it has multiple potential applications. BioSustane can be used as:
- A carrier for amorphous solid dispersion for poorly water-soluble drugs
- A sustained-release excipient compatible with both water-soluble and poorly water-soluble drugs
- An abuse-deterrent excipient when formulating APIs that are subject to abuse
- A novel depot former for injectable drugs as shown in some U.S. Food and Drug Administration (FDA) approved drug formulations. Note: Eastman does not market an injectable grade of BioSustane. Customer is responsible for ensuring BioSustane meets injectable grade.
In addition, the mucoadhesive property of BioSustane is hypothesized to enhance the bioavailability of the APIs.
Webinar with Walter Thompson – join here to watch it on demand
More product information – click here
See also the next article in the new excipients series