Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders

The relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and δ D-mannitol were assessed in this study with regards to their manufacturability. D-mannitol is a commonly used excipient in pharmaceutical formulations, especially in oral solid dosage forms, and can be crystallized as three polymorphic forms, of which β is the thermodynamically most stable form and δ is a kinetically stabilized polymorph. A systematic analysis of the powders as starting materials and their respective roller compacted granules is presented to elucidate the multidimensional effects of powder and granules characteristics such as polymorphic form, particle size, and preprocessing on the resulting tablets’ mechanical properties. In direct compression and after roller compaction, δ polymorph displayed superior tableting properties over β mannitol, but was outperformed by spray granulated β mannitol. This could be primarily correlated to the higher specific surface area, leading to higher bonding area and more interparticle bonds within the tablet. Hence, it was shown that surface characteristics and preprocessing can prevail over the impact of polymorphism on manufacturability for oral solid dosage forms.

Download the full study as PDF here Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders

or read it here

Materials

β mannitol (Pearlitol^® 160C) was acquired from Roquette Frères (Lestrem, France), and δ mannitol (Parteck^® Delta M) and spray granulated β mannitol (Parteck^® M200) were supplied by Merck KGaA (Darmstadt, Germany). Magnesium stearate was purchased from Peter Greven (Bad Münstereifel, Germany). All powders were sieved through a 1 mm sieve using a Turbosieve BTS 100 (L.B. Bohle, Ennigerloh, Germany) with a speed of 355 rpm. The influence of initial powder particle size on granules and tablet properties was investigated by comparison of two different particle size distributions of β mannitol powder: the initial 1 mm turbosieved powder and a fraction smaller than 180 µm of the β mannitol (180 β mannitol) powder. Therefore, after sieving with the turbosieve, a fraction of Pearlitol^® 160C powder was again manually sieved through a sieve with a mesh size of 180 µm (Retsch GmbH, Haan, Germany) before further processing.

Mareczek, L.; Riehl, C.; Harms, M.; Reichl, S. Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders. Pharmaceutics 2022, 14, 2128. https://doi.org/10.3390/pharmaceutics14102128

excipients formulation