MCC Spheres Facilitate Precise Dissolution Profile of Controlled Release Formulations
A 100% MCC sphere, Celphere™ has high sphericity and narrow particle size distribution. Also, Celphere™ is less damaged during film coating process because of its high mechanical strength. With regard to comparison with sugar spheres, Celphere™ can prevent agglomeration during film coating process because of its moderate water absorption capacity without dissolving. In addition, film coated granules with Celphere™ are more robust against external shear stress such as the gastrointestinal tract because of its insolubility. These functions and features of Celphere™ facilitates precise dissolution profiles of controlled release formulations.
We offer 5 grades of Celphere™ with different particle size ranges
| Grade | Particle size range (μm) | Sphericity | Bulk density (g/ｍL) | Water absorption (%) |
|---|---|---|---|---|
| CP-102 | 106-212 | 1.2 | 0.83 | 100 |
| CP-203 | 150-300 | 1.1 | 0.87 | 100 |
| CP-305 | 300-500 | 1.1 | 0.97 | 110 |
| CP-507 | 500-710 | 1.2 | 0.97 | 70 |
| CP-708 | 710-850 | 1.2 | 0.93 | 65 |
All values presented here are solely for the purpose of basic reference and should not be regarded as specifications
Source: Asahi Kasei