A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development
Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast datasets, requiring advanced analytical techniques for deeper understanding of data itself. Machine learning is becoming an important tool in the rapidly changing field of pharmaceutical research, particularly in drug preformulation studies.
This work aims to explore into the application of machine learning methods for the analysis of experimental data obtained by ODF characterization in order to obtain an insight into the factors governing ODF performance and use it as guidance in pharmaceutical development. Using a dataset derived from extensive experimental studies, various machine learning algorithms were employed to cluster and predict critical properties of ODFs.
Our results demonstrate that machine learning models, including Support vector machine, Random forest and Deep learning, exhibit high accuracy in predicting the mechanical properties of ODFs, such as flexibility and rigidity. The predictive models offered insights into the complex interaction of formulation variables. This research is a pilot study that highlights the potential of machine learning as a transformative approach in the pharmaceutical field, paving the way for more efficient and informed drug development processes.
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Materials
Eight hydrophilic polymers were investigated as film-forming agents: (1) hydroxypropyl cellulose (HPC, Klucel® GF, Ashland™, USA), (2) hypromellose (HPMC, Pharmacoat 606, Shin-Etsu Chemical Co., Japan); (3) carboxymethylcellulose sodium salt (CMC-Na, Fluka Chemie AG, Switzerland), (4) polyethylene glycol–polyvinyl alcohol graft copolymer (PVA-PEG, Kollicoat® IR, BASF, Germany), (5) maltodextrin (MDX, Glucidex IT12, Roquette, France), (6) sodium alginate (SA, Fisher Scientific, USA),
Erna Turkovic, Ivana Vasiljevic, Jelena Parojcic, A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development, International Journal of Pharmaceutics,
2024, 124188, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2024.124188.
Read also our introduction article on Alginates here:
