Towards the prediction of barrel fill level in twin-screw wet granulation
The barrel fill level is defined as the fraction of the free available volume for a given screw configuration that is occupied by the wet material and is an interplay of the material throughput, screw speed, screw setup, barrel length of the twin-screw granulator used and the properties of the starting material. The fill level has a major impact on mixing and densification of the wetted mass and thus on the granules produced. It influences the twin-screw granulation process accordingly.
In the current study, a model has been developed which is predictive in terms of material hold-ups in the barrel at various process settings by considering the geometries of the different screw elements in a configuration and the conveying velocity of the wet mass through the barrel. The model was checked on two granulators of different dimensions with various screw configurations, different materials and at different process settings.
The model represents a step forward in predicting the barrel fill level but further research with a broader spectrum of materials, screw configurations and process settings is still needed and additional twin-screw granulators of other dimensions must be investigated.
3.1. Materials
Materials used in the study were microcrystalline cellulose (MCC) (Vivapur® 102, JRS Pharma, Rosenberg, Germany), dicalcium phosphate anhydrous (DCPA) (DI-CAFOS® A12, Chemische Fabrik Budenheim, Budenheim, Germany) and lactose monohydrate (FlowLac®100, Meggle, Wasserburg am Inn, Germany). Demineralised water was used as granulation liquid.
Download the full study Pre-proof as PDF here: Towards the prediction of barrel fill level in twin-screw wet granulation (Pre-proof)
or read it here
Sebastian Pohl, Katrina Frey, Peter Kleinebudde, Towards the prediction of barrel fill level in twin-screw wet granulation, European Journal of Pharmaceutics and Biopharmaceutics, 2024, 114428, ISSN 0939-6411,
https://doi.org/10.1016/j.ejpb.2024.114428.
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