Difference in the Dissolution Behaviors of Tablets Containing Polyvinylpolypyrrolidone (PVPP) Depending on Pharmaceutical Formulation After Storage Under High T
ABSTRACT PURPOSE
Storage under high temperature and humid conditions has been reported to decrease the dissolution rate for some kinds of tablets containing polyvinylpolypyrrolidone (PVPP) as a disintegrant. The aim of this study was to elucidate the properties of pharmaceutical formulations with PVPP that cause a decrease in the dissolution rate after storage under high temperature and humid conditions by using model tablets with a simple composition.
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Received, August 25, 2016; Revised, November 25, 2016; Accepted, December 9, 2016; Published, December 11, 2016.
J Pharm Pharm Sci (www.cspsCanada.org) 19(4) 511 – 519, 2016