Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
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In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
– Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
– Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
– How to avoid precipitation and create a concentration gradient to improve absorption
– Methods for modelling the performance such as Molecular Dynamics Simulations
– In vitro methods for solubility and dissolution assessments
– Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
– Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)
Open access article link
or get the full PDF Successfuloraldeliveryofpoorlywater-solubledrugs