FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF SALBUTAMOL SULPHATE USING XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE POLYMER BLE
Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency…