Local drug delivery to the esophagus is hampered by rapid transit time and poor permeability of the mucosa. If some strategies aimed to improve the residence time have been proposed, non-invasive approaches to increase the drug penetration…

Abstract The development of RNA and oligonucleotide-based therapeutics is a longstanding goal and is currently gaining significant attention. Several RNA-based drugs are approved for clinical use. Others are under investigation or in…

Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system until reaching the stomach. Previous studies have provided evidence that…

Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF…

Alginate-based pharmaceutical formulations have been successfully used to treat the symptoms of gastroesophageal reflux disease (GERD) for decades and have a rapid onset of symptom relief. In the last twenty years, the knowledge and…

Abstract Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary…

Abstract The influences of the punch face design on multi-unit pellet system (MUPS) tablets were investigated. Drug-loaded pellets coated with sustained release polymer based on ethylcellulose or acrylic were compacted into MUPS tablets.…

Oral drug administration through solid oral dosage forms (SODF) remains the predominant method of drug therapy in both primary and secondary healthcare settings. This is particularly pertinent in the context of an aging population, where…

Abstract Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with…

Abstract Gastrointestinal diseases offer a serious potential hazard to people's health due to their high morbidity, mortality, and low early diagnosis rates. Due to its location within the body, the gastrointestinal tract is relatively…