Conventional spray drying using a 2-fluid nozzle forms matrix microparticles, where drug is distributed throughout the particle and may not effectively mask taste. In contrast, spray drying using a 3-fluid nozzle has been reported to…

Abstract Orally disintegrating granules (ODGs) are a pharmaceutical form commonly used for the administration of NSAIDs because of their easy assumption and fast dispersion. The development of ODGs is not easy for drugs like dexketoprofen…

In a 2003 survey conducted by the American Association of Pediatrics, unpleasant taste was identified as the most significant barrier to completing treatment in pediatrics. Drug taste masking is extremely relevant to improve patient…

Did you know that based on the virtual tool BitterPredict, about 40% of random molecules, 66% of clinical and experimental drugs, and almost 77% of natural products are bitter1? This leads us to concern about the final formulation's…

Introduction Taste-masking is typically considered to overcome the bitter or unpleasant taste of an active pharmaceutical ingredient, leading to a higher patient compliance and acceptability. Different techniques are available to obtain…

Taste is the most crucial organoleptic parameter affecting patient compliance in the case of drugs with poor palatability. Taste masking is a major challenge for the development of orally ingested active pharmaceutical constituents in the…

Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the application. Due to their direct contact…

Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve…

Pharmaceutical products often have drawbacks of unacceptable taste and palatability which makes it quite difficult for oral administration to some special populations like pediatrics and geriatrics. To curb this issue different approaches…