Alginate excipients are versatile biopolymers derived from various natural sources, primarily seaweed, and have gained significant prominence in the pharmaceutical industry due to their diverse applications. The pharmaceutical industry relies on alginates for their exceptional properties, which include gelling ability, controlled drug release, and biocompatibility.
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Alginates
Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery
Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant potential in colonic drug delivery due to their unique…
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Chitosan-coated alginate (CCA) nanoparticles for augmentation of topical antihistaminic activity of…
Abstract
Objective
The aim of the present study was to formulate chitosan-coated alginate nanoparticles containing the drug diphenhydramine hydrochloride (DHH).
Significance
Diphenhydramine hydrochloride (DHH) is the prototype of H1-antihistaminic drugs. It is a lipophilic drug, that…
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Mucoadhesive Pentoxyfylline Microsphere for Non-Invasive Nasal Drug Delivery
The aim of this study was to formulate and evaluate mucoadhesive sodium alginate microspheres for nasal administration of Pentoxifylline to avoid first-pass metabolism. Microspheres were prepared using an ionic gelation process using a 23 -factorial design. We investigated the effects of several…
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A Shrewd Ingenious Approach of Oral Drug Delivery of Insulin for the Amelioration of Diabetic…
Since 1922, insulin has saved the lives of countless people. However, the difficulties of subcutaneous administration, the need for frequent glucose self-monitoring, and the non-physiological action profiles of insulin prompted many medical professionals and patients to ask fornon-injectable insulin…
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Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets
Abstract
Background: Prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age.
Objective: To improve patient compliance by masking the bitter taste of the drug to be delivered as an orodispersible tablet.…
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Immediate-release dosage form; focus on disintegrants use as a promising excipient
Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with water in the GI tract. Immediate drug release dosage forms…
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Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition can be modified to allow slower disintegration and release of…
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Design, formulation, and evaluation of risperidone mucoadhensive buccal patches
Objectives: To construct and optimize Risperidone (RIS) mucoadhesive buccal films for systemic distribution as an alternate route. To make buccal patches of Risperidone utilizing natural polymers such sodium alginate (SA), Hydroxypropyl methylcellulose (HPMC), Na CMC, and Carbopol 934 (CP 934).…
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Recent Research Advances on Oral Colon-Specific Delivery System of Nature Bioactive Components: A…
Oral colon-specific delivery system (OCDS) is a targeted approach that aims to directly deliver bioactive compounds directly to the colon following oral administration, thereby enhancing the colonic release of bioactive substances and minimizing adverse reactions. The effectiveness of bioactive…
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Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast…
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline…
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