Alginate excipients are versatile biopolymers derived from various natural sources, primarily seaweed, and have gained significant prominence in the pharmaceutical industry due to their diverse applications. The pharmaceutical industry relies on alginates for their exceptional properties, which include gelling ability, controlled drug release, and biocompatibility.
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Alginates
Micro array patch assisted transdermal delivery of high dose, ibuprofen sodium using…
Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated in situ skin depots were evaluated for sustain drug delivery using sodium alginate/Poly (vinylcaprolactam) thermoresponsive gels. Their phase transition property…
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Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion-Templated Drug…
Hydrophobic active pharmaceutical ingredients (APIs) are ubiquitous in the drug development pipeline, but their poor bioavailability often prevents their translation into drug products. Industrial processes to formulate hydrophobic APIs are expensive, difficult to optimize, and not flexible enough…
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Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid…
Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory,…
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Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures
Abstract
In the biomedical field, extrusion-based 3D bioprinting has emerged as a promising technique to fabricate tissue replacements. However, a main challenge is to find suitable bioinks and reproducible procedures that ensure good printability and generate final printed constructs with high…
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Nanocellulose-Based Film-Forming Hydrogels for Improved Outcomes in Atopic Skin
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by impaired skin barrier function. Amongst the various dermal formulations that are being used and/or investigated for AD treatment, one of the advanced approaches is the use of hydrogels as film-forming systems that are…
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Evaluating spray gelation and spray freeze drying as the granulation method to prepare oral tablets…
Amorphous drug nanoplex represents one of the most promising solubility enhancement strategies of poorly-soluble drugs. Solubility enhancement capability of nanoplex hitherto has been demonstrated for nanoplex suspension and lyophilized/spray-dried nanoplex, but not for its oral tablets. Using…
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Optimization and Evaluation of Lisinopril Mucoadhesive Sustained Release Matrix Pellets: In-Vitro…
Lisinopril (LIS) it is antihypertensive drug, classified as a class III drug with a high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR) matrix pellet by extrusion/spheronization. Matrix pellets were…
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Comparison of the Behavior of 3D-Printed Endothelial Cells in Different Bioinks
Biomaterials with characteristics similar to extracellular matrix and with suitable bioprinting properties are essential for vascular tissue engineering. In search for suitable biomaterials, this study investigated the three hydrogels alginate/hyaluronic acid/gelatin (Alg/HA/Gel), pre-crosslinked…
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Soft capsule technology: modified pea starch as a vegetal origin alternative to gelatin in capsule…
Introduction
Gelatin has been used as shell polymer in the manufacture of soft gelatin capsules (softgels) for about the past century. Its rheological and thermal properties offer adequate balance for subsequent process steps including gel solution preparation/transportation, film casting, and…
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Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine diseases
Gynaecological health is a neglected field of research that includes conditions such as endometriosis, uterine fibroids, infertility, viral and bacterial infections, and cancers. There is a clinical need to develop dosage forms for gynecological diseases that increase efficacy and reduce side…
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