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Amino Acids
Towards the Development of a Cream with Antiviral Properties Targeting Both the Influenza A Virus…
Abstract
Objective: Many severe acute respiratory infections are caused by viral pathogens, and viruses are responsible for a large number of deaths worldwide. Among the most common respiratory viruses are the influenza A virus (IAV) and, more recently, the SARS-CoV-2 that emerged in 2019 and…
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Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine…
Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass metabolism in the liver. The aim of this project was to enhance the systemic…
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Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders
Rare diseases are infrequent, but together they affect up to 6–10 % of the world’s population, mainly children. Patients require precise doses and strict adherence to avoid metabolic or cardiac failure in some cases, which cannot be addressed in a reliable way using pharmaceutical compounding. 3D…
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Enhancement of inhaled micronized powder flow properties for accurate capsules filling
Introduction
Dry powder inhalers (DPI) are gaining popularity in the field of pulmonary treatments due to their numerous advantages. Compared to pressurized metered-dose inhalers (pMDI), soft-mist inhalers (SMI), and nebulizers, which utilize liquid formulations, DPIs employ solid-state…
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A review on natural biopolymers in external drug delivery systems for wound healing and atopic…
Abstract
Despite the advantages of topical administration in the treatment of skin diseases, current marketed preparations face the challenge of the skin's barrier effect, leading to low therapeutic effectiveness and undesirable side effects. Hence, in recent years the management of skin wounds,…
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Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D…
Three-dimensional (3D) printing is a potential technique for developing personalized medicines. Among its applications, mold manufacturing in industrial 3D printing stands out, especially for creating complex structures. This capability has been innovatively extended to drug development. Our study…
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Recent advances of electrospray technique for multiparticulate preparation: Drug delivery…
Abstract
The electrospray (ES) technique has proven to be an effective and a versatile approach for crafting drug delivery carriers with diverse dimensions, multiple layers, and varying morphologies. Achieving the desired particle properties necessitates careful optimization of various experimental…
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Tailoring drug release in bilayer tablets through droplet deposition modeling and injection molding
Abstract
This study explores the innovative production of personalized bilayer tablets, integrating two advanced manufacturing techniques: Droplet Deposition Modeling (DDM) and Injection Molding (IM). Unlike traditional methods limited to customizing dense bilayer medicines, our approach uses…
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Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia
Abstract
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol…
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A Comprehensive Review of Disintegrants: Backbone of disintegration
Abstract
Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents,…
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