Browsing Category
Amino Acids
Data-Driven Prediction of the Formation of Co-Amorphous Systems
Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms. However, the choice of the co-former is critical for the formation of a…
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Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate…
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Synthesize of the chitosan-TPP coated betanin-quaternary ammonium-functionalized mesoporous silica…
Advanced glycation end products (AGEs) are harmful by-products of thermal-processing of food. Betanin is an antioxidant with the potential to inhibit AGEs formation. In this work, we encapsulated betanin in chitosan-sodium tripolyphosphate coated quaternary ammonium-functionalized mesoporous silica…
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Construction of Bio-conjugated nano-vesicles using non-ionic surfactants for targeted drug delivery:…
Introduction
Targeted delivery of drugs to the brain is a complicated activity. This complication is caused by the blood–brain barrier (BBB). Interestingly, there are various transporters on the surface of the BBB that are naturally used for the transportation of specific compounds. A practical…
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Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering
Chronic wounds (resulting from underlying disease, metabolic disorders, infections, trauma, and even tumours) pose significant health problems. In this work, microparticles, based on polysaccharides (maltodextrin or dextran) and amino acids, and doped with antibacterial nanoparticles (CuO or ZnO…
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On the Utility of Chemical Strategies to Improve Peptide Gut Stability
Abstract
Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a key bottleneck in oral peptide drug development. Here, we present a systematic analysis of (i) the gut stability of disulfide-rich peptide scaffolds, orally administered peptide therapeutics,…
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PMC Isochem – Your partner for Smart & Innovative Solutions
See in the following a part of the company brochure by PMC Isochem
PMC Isochem offers Drug Delivery solutions, CDMO services and Active Pharmaceutical Ingredients and intermediates:
From development to GMP production of Amphiphilic and hydrophilic polymers for pharmaceutical…
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isodel PAA – PMC Isochem as CDMO for PolyAmino Acids
See in the following the overview on the usage fields of polyamino acids and the service spectrum of PMC Isochem as CDMO in this area:
Why PolyAmino Acids - PAA
Functional Excipients
Biodegradable Polymers
Drug Delivery & Drug Conjugate
Alternative to PEG (i.e. polysarcosine)…
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Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability
Proteins, the building blocks of life, are increasingly being used as therapeutics for treating several diseases. Yet, there are challenges in the delivery of highly labile materials like proteins, which is often circumvented with the help of encapsulation for targeted delivery and enhanced…
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Design and pharmacodynamic evaluation of DPK-060 loaded Nanostructured lipid carrier embedded gel…
DPK-060 is a synthetic, 17 amino acid peptide, structurally derived from the human protein kininogen. DPK-060 mainly acts by membrane disruption mechanism, thus demonstrating strong broad-spectrum antimicrobial activity against both gram-positive and gram-negative microbes, including…
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