Amino Acids

Still today, high-concentration protein formulations are often developed based on high-throughput experimental screening approaches. Although likely delivering working formulations, these approaches do not lead to a deep/mechanistic understanding of the protein phase behavior in solution. Within…
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The present study deals with the self-assembly of a pure graft copolymer: Soluplus® and a non-ionic surfactant: Solutol® HS15 and focuses on their clouding behaviour in the presence of different additives viz. inorganic salts (NaF, NaCl, NaBr, NaI, NaNO3, KCl, KBr, KI), bile salts (sodium…
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Shield your protein of interest from challenging conditions throughout the manufacturing process and increase shelf life with Merck's high purity stabilizers. Learn how you can minimize regulatory and quality-associated risks in your biopharmaceutical manufacturing. Stabilizers – for biomolecule…
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Phage therapy has gained prominence due to the increasing pathogenicity of “super bugs” and the rise of their multidrug resistance to conventional antibiotics. Dry state formulation of therapeutic phage is attractive to improve their “druggability” by increasing their shelf life, improving their…
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18. October 2016 Protein aggregation is a major problem of therapeutic proteins because aggregation decreases their therapeutic activity, shelf life and induces immunogenicity. Stabilization against aggregation is commonly attained by addition of different excipients like sugars,…
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