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antimicrobial
Unraveling the pharmaceutical and clinical relevance of the influence of syringic acid loaded…
Natural medicines are promising platforms for competent topical treatment modalities benefiting the cosmetic implementation and proffering solutions to the current remedies. Therefore, the objective of this study was to formulate syringic acid (SA), well-known for its multilateral anti-inflammatory,…
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Recent developments in improving the emulsifying properties of chitosan
Chitosan is one of the valuable products obtained from crustacean waste. The unique characteristics of chitosan (antimicrobial, antioxidant, anticancer, and anti-inflammatory) have increased its application in various sectors. Besides unique biological properties, chitosan or chitosan-based…
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The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment…
Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain…
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Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic…
Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and antibiotic resistance. Hydrogels are now being used as a new…
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Controlled and Local Delivery of Antibiotics by 3D Core/Shell Printed Hydrogel Scaffolds to Treat…
Soft tissue infections in open fractures or burns are major cause for high morbidity in trauma patients. Sustained, long-term and localized delivery of antimicrobial agents is needed for early eradication of these infections. Traditional (topical or systemic) antibiotic delivery methods are…
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Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher. Microbial drug depletion is often variable between and within individuals, depending on their…
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How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium…
The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against E. faecalis and C. albicans, associated with persistent endodontic…
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In situ solvent removal-based Eudragit®L/dimethyl sulfoxide forming gel for periodontal pocket drug…
Periodontitis is a chronic inflammatory disease of gum resulting from Porphyromonas gingivalis infectious at periodontal pockets. In situ forming gel (ISG) effectively delivers the antimicrobial agents to this targeted site. This study was to develop the dimethyl sulfoxide (DMSO) removal-based ISGs…
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Formulation of pH responsive multilamellar vesicles for targeted delivery of hydrophilic antibiotics
Fight against antimicrobial resistance calls for innovative strategies that can target infection sites and enhance activity of antibiotics. Herein is a pH responsive multilamellar vesicles (MLVs) for targeting bacterial infection sites. The vancomycin (VCM) loaded MLVs had 62.25 ± 8.7 nm, 0.15 ±…
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In Vitro and In Vivo Biological Assessment of Dual Drug-Loaded Coaxial Nanofibers for the Treatment…
The treatment of corneal abrasion currently involves the topical administration of antibiotics, with moxifloxacin HCl (0.5% w/v) eye drops being one of the most widely used treatments. Our previous work (Tawfik et al., 2020) involved the development of coaxial poly-lactic-co-glycolic acid (PLGA) and…
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