Binders play an important role in the tableting process of pharmaceuticals. They are used to improve the cohesion and plasticity of the powder mixture, which enhances the processability of the tablet and reduces the risk of tablet breakage during manufacture.
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Binder
A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction…
Abstract
This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon solid fraction. The classical Johanson’s model was integrated…
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Prediction of in-vitro dissolution and tablet hardness from optical porosity measurements
Abstract
Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs) have been developed and successfully implemented in…
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Evaluating Solubility, Stability, and Inclusion Complexation of Oxyresveratrol with Various…
Oxyresveratrol (OXY), a natural stilbenoid in mulberry fruits, is known for its diverse pharmacological properties. However, its clinical use is hindered by low water solubility and limited bioavailability. In the present study, the inclusion complexes of OXY with β-cyclodextrin (βCD) and its three…
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Evaluation of binders in twin-screw wet granulation – Optimization of tabletability
Abstract
The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the…
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Methocel™ Cellulose Ethers – A product that can do it all
THE POSSIBILITIES ARE ENDLESS
Pharmaceutical companies are continuously looking for ways to innovate – through new technologies such as controlled release systems and oral films, or through faster and more efficient manufacturing processes. Did you know that just one product can help do all of…
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TYLOPUR® – Water soluble cellulose ethers by Shin-Etsu
Introduction
TYLOPUR® is Hypromellose (HPMC) and a versatile pharmaceutical excipient. TYLOPUR® is manufactured at Tyloshin 2 plant at SE Tylose GmbH & Co. KG in Wiesbaden, Germany. This plant operates under GMP conditions and fulfills the requirements of the pharmaceutical industry. SE Tylose…
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Transfer of a rational formulation and process development approach for 2D inks for pharmaceutical…
The field of pharmaceutical 3D printing is growing over the past year, with Spitam® as the first 3D printed dosage form on the market. Showing the suitability of a binder jetting process for dosage forms. Although the development of inks for pharmaceutical field is more trail and error based,…
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L-HPC – Multifunctional excipient for oral solid dose by Shin-Etsu
L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) was developed by Shin-Etsu and first approved in 1977 as a disintegrant for tablets in Japan. New grades were developed during the last years in order to cover the needs for our customer having best solutions for individual applications.…
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Kollidon® 90 Evo – A highly effective water soluble binder with low impurity profile
Join the evolution of the BASF PVP portfolio! Kollidon® 90 Evo combines outstanding purity and innovative packaging.
Kollidon® 90 Evo is a highly effective binder with exceptional purity
Very low impurity profile, e.g., 2-pyrrolidone, aldehydes and hydrazine
Broad range of applications…
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PHARMACOAT® – Easy to use film coating material that provides an excellent finish
Shin-Etsu Chemical supplies the various excipients for pharmaceutical industry and developed PHARMACOAT® in the 1960s during the early days of film coating and since then it has been the subject of a continuous development and quality improvement.
The PHARMACOAT® grades are low viscous…
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