Evaluation of calcium magnesium silicate-date palm cellulose as a potential tablet excipient
A new excipient was prepared using natural resources and bio-wastes such as sodium silicate, brine and date palm cellulose. The prepared excipient is water-insoluble silicate salt precipitated in date palm cellulose (WISS-DPC). The aim of this study was to evaluate the potential use of this new material as an excipient for formulating oral solid dosage forms. Diclofenac sodium and paracetamol tablets were manufactured using direct compression and wet granulation methods, respectively. The surface of the tablets was studied using AFM and SEM. FTIR and DSC provided a guarantee of compatibility of the excipient with the model drugs. T6362-evaluation-of-he prepared tablets passed Pharmacopeial and Non-Pharmacopeial tests. Tablets prepared using WISS-DPC were harder, had rapid disintegration and rapidly dissolved compared to those produced with microcrystalline cellulose. The compactibility of the WISS-DPC was not affected by dilution with drugs or wet granulation. This new excipient could be used in pharmaceutical industry.
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