A Fast release tablet containing Herbal extracts (Ginger, Cinnamon, Turmeric, Long pepper and Punarnava)

The aim of the present work is to formulate a fast release tablet containing herbal extracts (ginger, cinnamon, turmeric, long pepper and punarnava) as drug, by direct compression method. Tablets contain super-disintegrant which disintegrate and dissolve fast and give its rapid onset of action. The effect of various superdisintegrants on the disintegration was studied. Croscarmelose sodium (CCS), crospovidone (CP) and sodium starch glycolate (SSG) were selected as a superdisintegrants. The study involved chromatographic fingerprinting of five drug extracts; cinnamon (Cinnamomum Zeylanicum Nees), long pepper (Piper longum, Linn.), turmeric (curcuma longa linn), punarnava (Boerhaavia diffussa linn.) and ginger (Zingiber officinalis, Rosc.) for standardization followed by preparation of tablets by direct compression methods. Infrared (IR) spectroscopy, performed to check out compatibility of drug extracts and the excipients. Powder blend of drug and excipients was investigated for the micromeritic properties. Evaluation of FDT was carried out for appearance, hardness, thickness, and weight variation, friability, and disintegration time and dissolution studies. Dissolution studies were carried out of all the formulations (F1 – F9). All formulations are compared with the marketed formulation (MF) and it was found that prepared formulations show better results. Continue on fast release tablets

KEYWORDS: Extracts (ginger, cinnamon, long pepper, turmeric and punarnava), fast dissolving tablets, IR.