Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies
![Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies](https://www.pharmaexcipients.com/wp-content/uploads/2021/01/KCI-pellets-after-compression.png)
Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets.
Download the full article here: Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies
or continue reading here: Sántha, K., Kállai-Szabó, N., Fülöp, V. et al. Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies. AAPS PharmSciTech 22, 14 (2021). https://doi.org/10.1208/s12249-020-01902-x
Materials
Ph. Eur. 8th grade potassium chloride, Microcrystalline cellulose (Avicel© PH105 and PH-302), Dimethicone, Aerosil®200, Eudragit NE 30 D acrylic film-forming polymer, Micronized talc, indigo carmine, Ethanol (96%), Silicone emulsion of SE2 type, emulgent (Labrafil©M 1944 CS), hydroxypropyl-methylcellulose (HPMC; Benecel© E3 Pharm)
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