Browsing Category
Bioavailability enhancement
Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded…
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It is a poor glass former, that shows high recrystallization tendency from the amorphous and supersaturated state, resulting in low…
Read More...
Read More...
pH Independent Bi-layer Self-microemulsifying Tablets (SMETs) of Candesartan Cilexetil with…
INTRODUCTION
CANDESARTAN CILEXETIL (CDC)
An angiotensin II receptor antagonist is a prodrug which gets converted to active drug Candersartan during absorption from the gastrointestinal tract.
The conventional CDC tablets have a significantly low bioavailability of approximately 14% after oral…
Read More...
Read More...
Self-Nano-Emulsifying Drug-Delivery Systems: A Limelight on the Development, Advancements and…
Abstract
Back ground: Orally administered medication solubility is a key concern for the pharmaceutical business; about 35-40% of newly introduced pharmaceuticals have less aqueous solubility, resulting in deprived dissolution and limited bio-availability. Employment of lipid-oriented drug release…
Read More...
Read More...
Enhanced Bioavailability of Valsartan through Mucoadhesive Pellets Fabricated via Fluidized Bed…
ABSTRACT
Background
Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention.
Aim
This study aimed to develop…
Read More...
Read More...
In Vitro Predictive Model for Intestinal Lymphatic Uptake: Exploration of Additional Enhancers and…
Abstract
Drug absorption via chylomicrons holds significant implications for both pharmacokinetics and pharmacodynamics. However, a mechanistic understanding of predicting in vivo intestinal lymphatic uptake remains largely unexplored. This study aimed to delve into the intestinal lymphatic uptake…
Read More...
Read More...
Systematic Development of Hot Melt Extrusion-Based Amorphous Solid Dispersion: Integrating Quality…
Abstract
Purpose
The study aimed to develop and optimize apremilast (APST) solid dispersion formulations using copovidone (Kollidon VA64) as the carrier and vitamin E TPGS as the surfactant to enhance solubility and dissolution, and to utilize in silico Physiologically Based Biopharmaceutics…
Read More...
Read More...
Optimizing Bioavailability and Antihypertensive Activity of Carvedilol Cubosomes using D-Optimal…
Abstract
Carvedilol (CARV) -a nonselective β-receptor antagonist indicated in treatment of hypertension- suffers from poor oral bioavailability due to its poor solubility and hepatic first-pass metabolism. This study aimed to optimize CARV-loaded cubosomes to enhance oral CARV bioavailability and…
Read More...
Read More...
Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and…
Apocynin (APO) is a plant derived antioxidant exerting specific NADPH oxidase inhibitory action substantiating its neuroprotective effects in various CNS disorders, including epilepsy. Due to rapid elimination and poor bioavailability, treatment with APO is challenging. Correspondingly, novel…
Read More...
Read More...
Chitosan Nanoparticles for Intranasal Drug Delivery
Abstract
This manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment. Chitosan nanoparticles are shown to enhance brain…
Read More...
Read More...
An overview of the methods used to increase the dissolution rate of meloxicam for oral…
Abstract
Oral administration of a drug substance has become one of the most important drug delivery routes. In chronic diseases such as rheumatoid arthritis or osteoarthritis, oral forms of drugs are preferred, not only by patients but also by doctors. Meloxicam (MLX) is pharmacologically…
Read More...
Read More...