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Bioavailability enhancement
Enhanced Oral Bioavailability of Rivaroxaban-Loaded Microspheres by Optimizing the Polymer and…
This study aimed to develop microspheres using water-soluble carriers and surfactants to improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded microspheres with optimal carrier (poly(vinylpyrrolidone) K30, PVP) and surfactant (sodium lauryl sulfate (SLS))…
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Book Chapter: Rectal and Vaginal – Practical Pharmaceutics Part 3
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics contains essential knowledge on the preparation, quality…
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Development and pharmacokinetic evaluation of Neusilin® US2-based S-SNEDDS tablets for bosentan:…
The study reported here aimed to develop and optimize the S-SNEDDS tablet of bosentan (BOS) and to investigate its pharmacokinetic and biodistribution properties. The BOS-loaded SNEDDS have been developed and characterized in a previous study. The BOS-loaded SNEDDS formulation was converted to…
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Solving parenteral solubility challenges in the development of oncology therapeutics
It’s no secret that solubility and bioavailability issues continue to challenge formulators and drug developers. Approximately 60-90% of potential new active pharmaceutical ingredients (APIs) in development pipelines, and more than 40% of those in reformulation, are poorly water-soluble. (1) Due to…
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In Vitro and In Vivo Characterization of Transdermal Patch Loaded with Nanostructured Lipid Carrier…
The objective of the present research work was to enhance the bioavailability of dolutegravir sodium (anti-HIV drug) by loading the drug into a nanostructured lipid carrier (NLC), fabricated into the patch, and administered through a transdermal route. For this experimental work, six solid lipids,…
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Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of…
Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers. This study aimed to evaluate the rectal bioavailability of hollow-type suppositories (HTS) and understand the…
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Can the Oral Bioavailability of the Discontinued Prostate Cancer Drug Galeterone Be Improved by…
Galeterone, a novel prostate cancer candidate treatment, was discontinued after a Phase III clinical trial due to lack of efficacy. Galeterone is weakly basic and exhibits low solubility in biorelevant media (i.e., ~ 2 µg/mL in fasted simulated intestinal fluid). It was formulated as a 50–50 (w/w)…
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Nanoparticle oral absorption and its clinical translational potential
Oral administration of pharmaceuticals is the most preferred route of administration for patients, but it is challenging to effectively deliver active ingredients (APIs) that i) have extremely high or low solubility in intestinal fluids, ii) are large in size, iii) are subject to digestive and/or …
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Brain nanotargeted [131I] I-Rolapitant as a model for brain imaging: Intranasal formulation,…
The goal of this study was to create a novel single-photon emission computed tomography (SPECT) probe that would enable the visualization of neurokinin-1 NK1 receptor systems in the brain for the precise diagnosis and follow-up of many brain-related disorders. Rolapitant (RT), a selective,…
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Oral Bioavailability Enhancement of Docetaxel by Preparation of Freeze-Dried Ternary Solid…
Abstract
Purpose
The poor solubility and permeability of docetaxel have limited its oral delivery. The current study was aimed at formulating the ternary solid dispersion of docetaxel for treatment of breast cancer and evaluating its oral bioavailability.
Methods
The solid dispersions of…
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