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Bioavailability enhancement
Thiolated polymers: An overview of mucoadhesive properties and their potential in drug delivery via…
Abstract
Thiolated polymers, or thiomers, are a class of polymers that exhibit unique mucoadhesive properties, allowing them to form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins. This property makes them ideal for developing drug delivery systems (DDSs) for various dry…
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Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the…
Coenzyme Q10 is a potent antioxidant that plays an important role in the maintenance of various biochemical pathways of the body and has a wide range of therapeutic applications. However, it has low aqueous solubility and oral bioavailability. Mesoporous silica nanoparticles (MCM-41 and SBA-15…
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Use of surfactant-based amorphous solid dispersions for BDDCS class II drugs to enhance oral…
This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing surfactant-based amorphous solid dispersions using resveratrol (RES) as a model drug. After preliminary screening of…
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Novel long-acting brimonidine tartrate loaded-PCL/PVP nanofibers for versatile biomedical…
The global state of antibiotic resistance highlights the necessity for new drugs that can treat a wide range of microbial infections. Drug repurposing has several advantages, including lower costs and improved safety compared to developing a new compound. The aim of the current study is to…
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Design and Optimization of Quercetin-Loaded Polymeric Eudragit L-100 Nanoparticles for Anti-diabetic…
To design and develop a nanoformulation from isolated quercetin (QT) from the Annona reticulata Linn leaves to enhance therapeutic index, solubility, bioavailability, toxicity mitigation, pharmacological activity improvement, and prevention of physical and chemical degradation of antidiabetic lead…
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Enhancement of Valsartan Oral Bioavailability by Preparing a Microwave-Irradiated Inclusion Complex…
The purpose of the study is to investigate the influence of sulfobutyl ether β-cyclodextrin (SBE7-β-CD) on the bioavailability of valsartan. Phase solubility investigations showed an AL type curve. The estimated apparent stability constant for valsartan SBE7-β-CD is 427 ± 0.32 M−1. Inclusion…
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Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly…
A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are…
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Preparation of Melatonin Nanoparticles and their Enhancement of Lungs Bioavailability in the…
Background: To develop a first-time-novel polymeric NPs from PLGA and their coating by Chitosan (CS) of Melatonin (MT) for the enhancement of lungs bioavailability by targeting lungs from the nose.
Materials and Methods: The Melatonin LC-MS/MS method was developed for the first time for a…
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Encapsulation of Morin in Lipid Core/PLGA Shell Nanoparticles Significantly Enhances its…
Morin (3,5,7,2′,4′-pentahydroxyflavone; MR) is a bioactive plant polyphenol whose therapeutic efficacy is hindered by its poor biopharmaceutical properties. The purpose of this study was to develop a nanoparticle (NP) formulation to enhance the bioactivity and oral bioavailability of MR. The…
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Development and Characterization of the Floating Beads Containing the BCS Class II Drug Lumafentrine…
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Gastroretentive systems can remain in the gastric region for several hours and significantly prolong the gastric residence of the drugs. Prolonged gastric retention improves bioavailability,…
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