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Bioavailability enhancement
Formulation and Evaluation of a Novel Multiparticulate Drug Delivery System for Poorely Water…
Ziprasidone hydrochloride Monohydrate ZHM, chemically 5- ethyl]-6-chloro-1, 3-dihydroindol-2-one hydrochloride; is an atypical antipsychotic with very poor water solubility and less oral bioavailability. The presented research work is about of preparation and evaluation of novel multiparticulate…
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Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through…
As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption…
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Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix…
The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating…
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Tubercular Drug Delivery Systems – Advances in Treatment of Infectious Diseases – Part…
The new book "Tubercular Drug Delivery Systems - Advances in Treatment of Infectious Diseases" book targets new advances in areas of treatment and drug delivery sciences for tuberculosis. It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies…
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Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent…
Nanotechnological drug delivery platforms represent a new paradigm for cancer therapeutics as they improve the pharmacokinetic profile and distribution of chemotherapeutic agents over conventional formulations. Among nanoparticles, lipid-based nanoplatforms possessing a lipid core, that is,…
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Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers…
Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders, such as schizophrenia and bipolar disorder. Nevertheless, adverse drug reactions jeopardize clinical outcomes, resulting in patient non-compliance. The design formulation strategies for enhancing brain drug…
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Unlock the Potential of Poorly Soluble Drugs with Apisolex™ Technology
Don’t let poor solubility affect your innovative drug projects
Approximately 60% of potential active pharmaceutical ingredients (APIs) under development, and more than 40% of those in reformulation, are poorly water soluble1. Solubility challenges present a substantial hurdle to the development…
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An investigation into solubility and dissolution improvement of alectinib hydrochloride as a…
Poorly water-soluble drugs belonging to BCS Class II and IV present a big challenge to formulators owing to their limited solubility and bioavailability. Alectinib hydrochloride (ALB), a BCS IV molecule, shows very low solubility resulting in low bioavailability. The objective of the present study…
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Recent Progress of Lipid Nanoparticles-Based Lipophilic Drug Delivery: Focus on Surface…
Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health. Approximately 40% of them are lipophilic and are used for treating diseases through various delivery routes, including skin absorption, oral administration, and injection. However, as…
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Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and…
It has been seventy years since a water-soluble version of vitamin E called tocophersolan (also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive ingredient. Drug formulation developers were initially intrigued by its surfactant qualities, and gradually it made its way…
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