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Bioavailability enhancement
Cyclodextrin-enabled nepafenac eye drops with improved absorption open a new therapeutic window
Nepafenac is a highly effective NSAID used for treating postoperative ocular inflammation and pain after cataract surgery and its advantage over conventional topical NSAIDs has been proved many times. However, Nevanac® is a suspension eye drop, which clearly lacks patient compliance causing…
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Recent Advances in Improving the Bioavailability of Hydrophobic/Lipophilic Drugs and Their Delivery…
Formulations based on emulsions for enhancing hydrophobic and lipophilic drug delivery and its bioavailability have attracted a lot of interest. As potential therapeutic agents, they are integrated with inert oils, emulsions, surfactant solubility, liposomes, etc.; drug delivering systems that use…
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Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro…
Repaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due to hepatic first pass metabolism. In this study, 2FI I-Optimal statistical design was employed to encapsulate RPG into…
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Dissolvable microneedles for transdermal drug delivery showing skin penetration and modified drug…
Topical therapies for chronic skin diseases suffer from a low patient compliance due to the inconvenient treatment regimens of available products. Dissolvable microneedles (MN) with modified release offer an interesting possibility to increase the compliance by acting as a depot in the skin and…
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Research progress of ophthalmic preparations of immunosuppressants
Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body’s immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug…
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Apisolex™ Polymer – by Lubrizol
Solubility-enhancing polymer for use in bolus injections and IV infusions
Lubrizol Life Science Health’s (LLS Health’s) Apisolex™ GMP, injectable-grade excipient is a safe, polyamino acid-based polymer that enhances the solubility of BSC Class II and IV APIs.
Formulation Benefits…
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A Systematic Overview of Eudragit® Based Copolymer for Smart Healthcare
Eudragit, synthesized by radical polymerization, is used for enteric coating, precise temporal release, and targeting the entire gastrointestinal system. Evonik Healthcare Germany offers different grades of Eudragit. The ratio of methacrylic acid to its methacrylate-based monomers used in the…
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Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for…
Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib (CXB) for enhancing its solubility and oral bioavailability.…
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Webinar – Latest outcomes from ex vivo and in vivo studies with Labrasol® ALF and Labrafac™…
Many drugs suffer from low oral bioavailability due to poor intestinal absorption (BCS Classes III and IV, peptides and macromolecules). Formulating with intestinal permeation enhancers can overcome this limiting factor. Medium chain fatty acids are reputed to increase intestinal permeation, among…
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Application of NMP and Neusilin US2-integrated liquisolid technique in mini-tablets for improving…
Frankincense and myrrh are widely used Chinese medicines, showing clinically relevant synergistic therapeutic effects in the treatment of inflammation and cancer. We investigated the applicability of a liquisolid (LS) technique to the preparation of mini-tablets containing supercritical fluid…
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