Browsing Category
Bioavailability enhancement
Processability and Oral Bioavailability Improvement of Itraconazole by Particle Engineering…
The current study aimed to improve the processability and oral bioavailability of itraconazole (ITZ) via spherical agglomeration. ITZ-spherical agglomerates (ITZ-SA) and ITZ-poloxamer 407-spherical agglomerates (ITZ-PLX-SA) were optimized using Box-Behnken design. Here, the drug release was affected…
Read More...
Read More...
Controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From…
The need for solutions in the pharmaceutical field that respond to the new needs regarding the minimum impact of the active pharmaceutical substances on the body has led to an explosion of research on smart systems for controlled drug delivery. Supramolecular chemistry has provided in recent years…
Read More...
Read More...
Improving in vivo oral bioavailability of a poorly soluble drug: a case study on polymeric versus…
Poorly soluble drugs must be appropriately formulated for clinical use to increase the solubility, dissolution rate, and permeation across the intestinal epithelium. Polymeric and lipid nanocarriers have been successfully investigated for this aim, and their physicochemical properties, and in…
Read More...
Read More...
Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles…
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral…
Read More...
Read More...
Compatibility Study between Fenbendazole and Polymeric Excipients Used in Pharmaceutical Dosage…
The body of work described in this research paper evaluates the compatibility between Fenbendazole (Fen), which is a broad-spectrum anthelmintic with promising antitumor activity, and three polymeric excipients commonly applied in pharmaceutical dosage forms. The assessment of binary mixtures was…
Read More...
Read More...
Thermoresponsive in-situ gel containing hyaluronic acid and indomethacin for the treatment of…
Ocular chemical burns are prevalent injuries that must have immediate and effective treatment to avoid complications. Aiming to improve bioavailability and efficacy, a poloxamer-based thermoresponsive in-situ gelling system containing hyaluronic acid and indomethacin was developed. Formulations with…
Read More...
Read More...
Preparation of nanodelivery systems for oral administration of low molecular weight heparin
Low molecular weight heparins (LMWHs) are only used parenterally. They have low oral absorption and bioavailability due to their high anionic charge density, exposure to enzymatic degradation and first pass effect. The aim of this study was the development and evaluation of nanodelivery systems to…
Read More...
Read More...
A Current Overview of Cyclodextrin-Based Nanocarriers for Enhanced Antifungal Delivery
Fungal infections are an extremely serious health problem, particularly in patients with compromised immune systems. Most antifungal agents have low aqueous solubility, which may hamper their bioavailability. Their complexation with cyclodextrins (CDs) could increase the solubility of antifungals,…
Read More...
Read More...
Co-carrier-based solid dispersion of celecoxib improves dissolution rate and oral bioavailability in…
This study aimed to prepare a co-carrier-based solid dispersion (SD) of celecoxib (CXB) to improve its dissolution and oral bioavailability. The CXB-loaded SD formulation was prepared using CXB, pol407, Aerosil 200, and Eudragit L100 at a weight ratio of 1:3:1.5:1. PXRD, DSC, and FTIR analyses were…
Read More...
Read More...
Exploring the effect of intramuscularly injected polymer/lipid hybrid nanoparticles loaded with…
The current study intended to develop a new treatment of schizophrenia having a sustained release activity. Quetiapine fumarate (QF)-loaded polymer/lipid hybrid nanoparticulate systems of polycaprolactone (PCL) and Geleol™ were fabricated using polyvinyl alcohol (3% w/v). The proposed hybrid systems…
Read More...
Read More...