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Bioavailability enhancement
Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets
Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property…
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Development and optimization of ganciclovir-loaded carbopol topical gel by response surface…
Low permeability is one of the barriers to the bioavailability of drugs through the oral route. The purpose of the present study was to design and optimize a sustained release and highly permeable hydrogel formulation of ganciclovir (GCV) by using response surface methodology (RSM). Carbopol 934P…
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Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and…
The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to…
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Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and…
Abstract
Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent.…
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Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations
The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved…
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Effect of Combination of Carbopol-940 Base and HPMC Gel Extract of Aloe Vera Flesh on Physical…
Aloe vera (Aloe chinensis Barker.) has been shown to be efficacious as an antibacterial which has the potential to treat acne caused by the bacteria Propionibacterium acnes. The use of this combination can increase the viscosity, dissolution, diffusion, and bioavailability of the preparation. This…
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Reduction of submicron particle agglomeration via melt foaming in solid crystalline suspension
Particle size reduction of poorly water-soluble drug crystals down to the submicron region (0.1–1 µm) is a focus strategy to increase bioavailability. In this context, solid crystalline suspensions (SCS) manufactured in an adapted wet milling process have been introduced as a promising formulation…
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BASF Pharma Solutions excipient accepted into FDA Pilot Program for novel excipients – Press…
Florham Park, New Jersey, December 5, 2022 –
BASF Pharma Solutions, a global business unit of BASF, announces today that the U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER), Office of New Drugs, has accepted their excipient, Soluplus®, into the FDA’s Pilot…
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Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin
Compared to subcutaneous injections, oral administration of insulin would be a preferred route of drug administration for diabetic patients. For oral delivery, both liposomes and alginate hydrogels face many challenges, including early burst release of the encapsulated drug and poor intestinal drug…
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Enhancing oral bioavailability of andrographolide via sodium dodecyl sulfate and D-α-Tocopherol…
Nanocrystal technology is a common strategy to enhance the oral bioavailability of poorly-soluble drugs, and how to enlarge the enhancing ability on oral absorption via nanocrystals has become a pharmaceutical research field. In this study, we selected andrographolide (ADR), a typical poorly-soluble…
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