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Bioavailability enhancement
Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous…
Lumefantrine, exhibits poor bioavailability due to its very low solubility. A liquisolid compact of lumefantrine was prepared with mesoporous silica as a novel coating material. Lactose anhydrous and syloid 244FP were selected as carrier and coating materials respectively. Varying the carrier to…
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Processing of Lipid Nanodispersions into Solid Powders by Spray Drying
Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve their bioavailability. Once the API-loaded nanocarriers have…
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Neither too little nor too much: finding the ideal proportion of excipients using confocal Raman and…
The applications of Raman imaging in pharmaceutical field are ever-increasing due its ability to obtain spatial and spectral information simultaneously, once it allows determine the chemical distribution of compounds. In this sense, it is used to study homogeneity, of paramount importance during the…
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Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis
Abstract
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease with unknown cause. It mainly affects joints and, without proper treatment, negatively impacts their movement, causes painful deformities, and reduces the patients’ quality of life. Current treatment options consist of…
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Formulate Robust, Fast Disintegrating Tablets with polyplasdone® crospovidone – Webinar
Do you want to learn how to optimize immediate release formulations in terms of disintegration performance?
Then register for our next free webinar:
Formulate Robust, Fast Disintegrating Tablets with polyplasdone® crospovidone.
Due to the complex interrelationships between raw material…
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Oral self-emulsifying nanoemulsion systems for enhancing dissolution, bioavailability and anticancer…
This research aimed to prepare a camptothecin (CPT) loaded self nano emulsifying drug delivery system (SNEDDS) that would improve the oral therapeutic efficacy of CPT. 32 full factorial design was employed, and the effect of the amount of oil (X1) and surfactant mixture (X2) was systematically…
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Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for…
The study was initiated with two major purposes: investigating the role of isomalt (GIQ9) as a pharmaceutical carrier for solid self-nanoemulsifying drug delivery systems (S-SNEDDSs) and improving the oral bioavailability of lipophilic curcumin (CUN). GIQ9 has never been explored for solidification…
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Sex-specific effects of excipients on oral drug bioavailability
The mechanism of action of excipients eliciting sex differences in drug bioavailability is poorly understood. In this study, the excipients Cremophor RH 40 (PEG 40 hydrogenated castor oil), Poloxamer 188 (2-methyloxirane) and Tween 80 (polyoxyethylene (80) sorbitan monooleate) were screened at 0.07…
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Trends in development and quality assessment of pharmaceutical formulations – F2α analogues in…
The ocular delivery route presents a number of challenges in terms of drug administration and bioavailability. The low bioavailability following topical ophthalmic administration shows that there is a clear need for in-depth research aimed at finding both more efficacious molecules and formulations…
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The impact of lactose type on disintegration: An integral study on porosity and polymorphism
Besides factors such as disintegrant and lubricant, the raw material properties of filler excipients can have an impact on the disintegration behavior of a tablet. The current research aims to model the impact of lactose properties on disintegration time. For the first time, the impact of lactose…
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