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Bioavailability enhancement
Design, Formulation, and Characterization of Valsartan Nanoethosomes for Improving Their…
The objective of this study was to formulate and evaluate valsartan (VLT) ethosomes to prepare an optimized formula of VLT-entrapped ethosomes that could be incorporated into a sustained release transdermal gel dosage form. The formulation of the prepared ethosomal gel was investigated and subjected…
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Oral Disintegrating Tablets – see the solution landscape
Introduction
Oral disintegrating tablets (ODTs) are patient-centric drug delivery systems (for example, for pediatrics, geriatrics, and psychiatric patients with dysphagia) designed to increase patient compliance. ODTs are preferred to classic dosage forms (swallowable / chewable / suckable…
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Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability,…
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature makes it difficult to develop a viable oral formulation. In…
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Preparation and evaluation of camptothecin analogues-loaded lyophilization using Kolliphor® HS 15 as…
FLQY2 is a camptothecin derivative modified by FL118 and proved to be good antitumor activity in vitro. However, its poor solubility leads to the low therapeutic efficacy in vivo. Here, the injectable FLQY2 lyophilized powder was prepared with Kolliphor® HS 15 (HS 15), which was called HS 15-FLQY2.…
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Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances…
In this study, poly (lactic-co-glycolic) acid (PLGA) particles were synthesized and coated with chitosan. Three essential oil (EO) components (eugenol, linalool, and geraniol) were entrapped inside these PLGA particles by using the continuous flow-focusing microfluidic method and a partially…
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New and Novel Excipients – Part 2
A week ago I wrote about the importance of new and novel excipients for the pharmaceutical industry and presented Klucel™ xtend and BioSustane™ in last week´s edition of "The Excipients Week".
In the meantime I launched a small poll with the title "Was there innovation in excipients over the last…
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Engineering the right formulation for enhanced drug delivery
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules and biologics and offer several advantages for inhaled therapy. Early DPI products were intended to treat asthma and lung chronic inflammatory disease by administering low-dose, high-potency drugs blended with…
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Considerations in the developability of peptides for oral administration when formulated together…
This paper reviews many of the properties of a peptide that need to be considered prior to development as an oral dosage form when co-formulated with a permeation enhancer to improve oral bioavailability, including the importance and implications of peptide half-life on variability in…
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Detrimental Effect of the Film Coat Chemistry and Thickness on the Physical Stability of Amorphous…
Amorphous solid dispersions (ASDs) have been widely utilized to enhance the bioavailability of pharmaceutical drugs with poor aqueous solubility. The role of various excipients on the amorphous drug to crystalline form conversion in ASDs has been widely documented. However, there has been no…
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Tunable Polymeric Mixed Micellar Nanoassemblies of Lutrol F127/Gelucire 44/14 for Oral Delivery of…
Hymenolepiasis represents a parasitic infection of common prevalence in pediatrics with intimidating impacts, particularly amongst immunocompromised patients. The present work aimed to snowball the curative outcomes of the current mainstay of hymenolepiasis chemotherapy, praziquantel (PRZ), through…
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