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Bioavailability enhancement
Development of a Novel Lipid-Based Nanosystem Functionalized with WGA for Enhanced Intracellular…
Despite a considerable number of new antibiotics under going clinical trials, treatment of intracellular pathogens still represents a major pharmaceutical challenge. The use of lipid nanocarriers provides several advantages such as protection from compound degradation, increased bioavailability, and…
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Surface modified Genistein phytosome for Breast Cancer Treatment: In-vitro Appraisal,…
Based on phytosomes advantages over liposomes, hyaluronic acid (HA) with/out pegylated phospholipid was used to develop surface-modified genistein (Gen) phytosome as Gen pegylated hyaluophytosomes (G-PHA) and Gen hyaluophytosomes (G-HA) as novel delivery systems for breast cancer treatment. In…
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Optimization of Lipid Nanoparticles by Response Surface Methodology to Improve the Ocular Delivery…
Diosmin is a flavonoid with a great variety of biological activities including antioxidant and anti-inflammatory ones. Its cytoprotective effect in retinal pigment epithelium cells under high glucose conditions makes it a potential support in the treatment of diabetic retinopathy. Despite its…
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Lipid-based nanocarriers for ocular drug delivery: An updated review
Recent years have witnessed a boom in ocular nanomedicine research with a number of lipid-based nanocarriers such as liposomes, niosomes, cubosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, etc., to improve the ocular bioavailability of a variety of drugs and…
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Poloxamer: a simple and powerful solution for accelerating dissolution
Oral administration is the most commonly employed route for drug delivery. It is cost-effective and convenient for the patient, leading to high patient compliance. In order for the API to exert a physiological effect it must pass from the gastrointestinal (GI) tract and into the systemic…
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Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle…
Micronized particles are commonly used to improve the content uniformity (CU), dissolution performance, and bioavailability of active pharmaceutical ingredients (API). Different particle engineering routes have been developed to prepare micron-sized API in a specific size range to deliver desirable…
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Andrographolide liquisolid using porous-starch as the adsorbent with enhanced oral bioavailability…
Andrographolide (AGL) is the major component of Andrographispaniculata. The poor water solubility and low dissolution strongly affect its oral absorption. Liquisolid technology has been used to improve its dissolution and oral bioavailability. Liquisolid powders of AGL (AGL-LS-PSG) were obtained by…
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Formulating Drug Products for Optimized Absorption: Elucidating Amorphous Solid Dispersions
CDER scientists are seeking ways to improve the bioavailability of drugs that on their own do not dissolve well in water. Recent CDER research explores the potential for using amorphous solid dispersions to formulate generic drug products that may include ingredients that are poorly water-soluble.…
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On the Utility of Chemical Strategies to Improve Peptide Gut Stability
Abstract
Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a key bottleneck in oral peptide drug development. Here, we present a systematic analysis of (i) the gut stability of disulfide-rich peptide scaffolds, orally administered peptide therapeutics,…
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In vitro profiling of fenofibrate solid dispersion mediated tablet formulation to treat high blood…
Objective:
Fenofibrate (FNF), an anti-hyperlipidemic agent, suffers from poor water solubility (0.000707 mg/ml) and belongs to class II drug as per BCS, shows a slow dissolution rate. The current investigation aimed to fabricate a fast-dissolving tablet of FNF (not available in the commercial…
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