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Bioavailability enhancement
Dissolution Behavior of Weakly Basic Pharmaceuticals from Amorphous Dispersions Stabilized by a…
Amorphous solid dispersions (ASDs) are a well-documented formulation approach to improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However, weakly basic compounds can complicate standard approaches to ASDs due to pH-dependent solubility, resulting in uncontrolled drug…
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Evaluation of the Formulation Parameter-Dependent Redispersibility of API Nanoparticles from Fluid…
The production of nanosuspensions of poorly soluble active pharmaceutical ingredients (API) is a popular technique to counteract challenges regarding bioavailability of such active substances. A subsequent drying of the nanosuspensions is advantageous to improve the long-term stability and the…
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A self-emulsifying omega-3 fatty acids delivery system for enhanced gastro-intestinal absorption in…
Omega-3 fatty acids have many health benefits as they help to prevent and treat coronary artery disease, hypertension, diabetes mellitus, arthritis, and autoimmune disorders. Omega-3 fatty acids miscible in lecithin were found to spontaneously form microemulsions in water. The particle sizes of…
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In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro evaluations of formulation principles in mice are still…
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isodel PAA – PMC Isochem as CDMO for PolyAmino Acids
See in the following the overview on the usage fields of polyamino acids and the service spectrum of PMC Isochem as CDMO in this area:
Why PolyAmino Acids - PAA
Functional Excipients
Biodegradable Polymers
Drug Delivery & Drug Conjugate
Alternative to PEG (i.e. polysarcosine)…
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Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis…
Osteoarthritis (OA) is a prevalent degenerative disease that has a significant impact on patients' lives. Celecoxib (CXB) is now primarily used to treat OA with oral dosing. CXB's limited water solubility, on the other hand, restricts its therapeutic application. We developed a delivery system of…
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Excipients for veterinary application – IOI Oleo
See an overview of the IOI Oleo specialties for Veterinary Applications.
They are used for companion as well as for farm animals in following uses:
• Injectables - SC and IM
• Infusions - IV
• Oral (e.g. paste, drench)
• Pour-on / Spot-on formulations
• Tick and flea collars
…
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The Impact of the Oil Phase Selection on Physicochemical Properties, Long-Term Stability, In Vitro…
A nanotechnology-based approach to drug delivery presents one of the biggest trends in biomedical science that can provide increased active concentration, bioavailability, and safety compared to conventional drug-delivery systems. Nanoemulsions stand out amongst other nanocarriers for being…
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Formulation, characterization and in-vitro evaluation of self-nanoemulsifying drug delivery system…
Self-nanoemulsifying drug delivery systems (SNEDDS) are most commonly used lipid-based drug delivery systems for bioavailability enhancement. Mostly SNEDDS contains high concentrations of synthetic surfactants which may result in gastric irritation and cause toxicity. In this study, Rhamnolipid, a…
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Nanostructured lipid carriers and their potential applications for versatile drug delivery via oral…
Abstract
Enteral administration is the most convenient route despite the gastrointestinal physiological barriers. Nanostructured lipid carriers (NLCs) have emerged as a promising strategy for improving therapeutic compound oral bioavailability, not only due to nanomaterial advantages, but also…
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