Browsing Category
Bioavailability enhancement
3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related…
Bacterial infections are a serious healthcare complication in orthopedic and trauma surgery worldwide. Compared to systemic, local antibiotic prophylaxis has been shown to provide a higher antibiotic dose and bioavailability at the bone site with minimum toxic effects. However, there are still not…
Read More...
Read More...
Comparative Study of Methods for the Pharmaceutical Preparation and Effectiveness of Darunavir…
Purpose
The aim of this work was to study the effectiveness of various methods for improving the solubility and bioavailability of darunavir by mesoporous carriers and water-soluble polymers in the form of amorphous solid dispersions.
Methods
Preliminarily, using the solvent wetting method, solid…
Read More...
Read More...
Lipid-based solubilization technology via hot melt extrusion: promises and challenges
Self-emulsifying drug delivery systems (SEDDS) are a promising strategy to improve the oral bioavailability of poorly water-soluble drugs (PWSD). The excipients of SEDDS enable permeation through the mucus and gastro-intestinal barrier, inhibiting efflux transporters (e.g. P-glycoprotein) of drugs.…
Read More...
Read More...
Cubosomes for Enhancing Intestinal Absorption of Fexofenadine Hydrochloride: In situ and in vivo…
Purpose: The aim of this work was to probe cubosomes for enhanced intestinal absorption and oral bioavailability of poorly absorbable fexofenadine HCl (FEX-HCl).
Materials and Methods: Two cubosomal systems were fabricated utilizing glyceryl mono-oleate, a lyotropic mono lamellar lipid as oil…
Read More...
Read More...
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense porous network that coats all the exposed epithelia not covered with the skin. The layer provides protection to the underlying gastrointestinal, respiratory, and female reproductive tracts, in addition to the…
Read More...
Read More...
Witepsol – Hard fats for suppositories and ovules by IOI Oleochemical
1| HARD FACTS ABOUT OUR HARD FATS
The brand name WITEPSOL® is synonym for hard fats mainly used in suppositories and ovules.
Development and production of WITEPSOL® started back in the 1950s at the former Chemische Werke Witten, now known as IOI Oleo GmbH.
Manufacturing takes place in a fully…
Read More...
Read More...
Microneedles assisted controlled and improved transdermal delivery of high molecular drugs via in…
Skin is considered as an attractive route for variety of drug molecule administration. However, it is proved to be the main physical barrier for drug flux owing to their poor permeability and low bioavailability across stratum corneum layer. In the current study, novel approach has been used to…
Read More...
Read More...
Targeted colonic release formulations of mesalazine – A clinical pharmaco-scintigraphic…
Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastrointestinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently…
Read More...
Read More...
Self-nanoemulsifying drug delivery system (SNEDDS) improves the oral bioavailability of betulinic…
Betulinic acid (BA) is a bioactive molecule with antineoplastic, antiviral, anti-inflammatory features; however, it exhibits low solubility in water, which limits its practical applications. Our work aims to develop self-nanoemulsifying drug delivery systems (SNEDDS) to improve the bioavailability…
Read More...
Read More...
Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce…
Colorectal cancer (CRC) is a heterogeneous disease with high incidence and mortality worldwide. The efficacy of conventional CRC chemotherapy is hampered by poor drug solubility and bioavailability and suboptimal pharmacokinetic profiles. In this work, camptothecin (CPT), a potent anticancer drug,…
Read More...
Read More...