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Bioavailability enhancement
The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug…
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Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for the enhancement of TCG solubility and permeability. Herein, we have developed the TCG high-loaded nanostructured lipid carrier (HL-NLC) and solidified…
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Biochar as a processing additive in poly (butylene adipate-co-terephthalate) (PBAT)
Poly (butylene adipate-co-terephthalate) (PBAT) is a promising alternative to non-biodegradable plastics in agricultural applications. However, it is usually blended with other materials to find a balance of strength, cost, and iodegradability. There is a need to understand the role of additives and…
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Kollidon® VA 64 and Soluplus® as modern polymeric carriers for amorphous solid dispersions
As the number of new drug candidates that are poorly soluble in water grows, new technologies that enable the enhancement of their solubility are needed. This is the case with amorphous solid dispersions (ASDs) that, nowadays, not only ensure the solubility, but can also be used to control the …
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Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery…
Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of…
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A Oral Fast Dissolving Films Containing Lyophilized Labetalol HCL with Hydroxy Propyl…
Introduction: Labetalol HCL is an antihypertensive drug used to treat high blood pressure in the long term management of angina. Labetalol HCL is readily absorbed after oral administration. Labetalol HCl undergoes considerable hepatic first-pass metabolism due to its lipid-soluble nature.…
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A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions:…
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in recent years, with the potential to improve the apparent solubility and, hence, the oral bioavailability of poorly soluble drugs. The process of formulating ASDs is commonly faced with challenges owing to the…
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Lipid based nanocarriers: Production techniques, concepts, and commercialization aspect
Over the past decade, compared to all other macromolecules lipid-based nanocarriers have proven to be an excellent carrier and delivery system for various pharmaceutical drugs of poor bioavailability. In addition to that, they exhibit exceptional qualities such as minimal toxicity, economical…
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Long acting injectables for therapeutic proteins
Biotherapeutic development presents a myriad of challenges in relation to delivery, in particular for protein therapeutics. Protein delivery is complicated due to hydrophilicity, size, rate of degradation in vivo, low permeation through biological barriers, pH and temperature sensitivity, as well as…
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Chitosan/sulfobutylether-β-cyclodextrin based nanoparticles coated with thiolated hyaluronic acid…
Indomethacin (IND) is topically administered for the treatment of the anterior segment diseases such as conjunctivitis, uveitis, and inflammation prevention for post-cataract surgery, as well as posterior segment diseases as macular edema. Currently IND is available as 0.1% w/v…
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