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Bioavailability enhancement
Formulation of immediate release pellets containing famotidine solid dispersions
Famotidine (FM) is a potent H2-receptor antagonist used for the treatment of peptic ulcer. It has a low and variable bioavailability which is attributed to its low water solubility. In this study, the dissolution of the drug was enhanced by a preparation of solid dispersion using two hydrophilic…
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A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion…
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot-melt extrusion (HME) technique. However,…
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Nanonutraceuticals — Challenges and Novel Nano-based Carriers for Effective Delivery and Enhanced…
Nutraceuticals, the active compounds found abundant in most of the natural products, have shown beneficial effects on human health. Their absorption when consumed is limited owing to their poor solubility and unsuitable chemical and physical properties. In order to empower the beneficial properties…
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Spray-dried indomethacin-loaded polymeric micelles for the improvement of intestinal drug release…
Current study aimed to develop a spray-dried powder containing indomethacin (IND)-loaded polymeric micelles which can be administered perorally as a dissolved powder to enhance the drug release and permeability of the active substance. The resulting low dense spray-dried spherical particles have…
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DoE Based Formulation Development and Characterization of Topical Nanoemulgel of Diacerein: In-Vitro…
Diacerein (DCN) is the class II rhein derivative with low oral bioavailability, although it has good anti-osteoarthritic action. Because of the potential to induce adverse effects when taken orally, the current study focused on producing a topical nanoemulgel formulation based on the 32 Box-Behnken…
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Synthesis and characterization of cinnamic acid based glyceride and its application for developing…
Curcumin (CU) possesses diverse pharmacological activities while being relatively safe; nevertheless, its clinical application is limited due to its physico-chemical characteristics. This study aimed to synthesize cinnamic acid based glyceride for use in a self-nanoemulsifying drug delivery system…
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Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for…
The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability of quercetin (QT). Quercetin nanocrystal (QT–NC) was fabricated by high pressure homogenization method, and QT–NSSPE was then prepared by ultrasound method with…
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Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug…
Lovastatin (Lov) is a lipid-lowering agent, with 5% bioavailability (BA) due to extensive first pass metabolism and poor solubility. To enhance dissolution and in vivo effects, Lov solid self microemulsifying drug delivery system (SMEDDS) and liquisolid systems were developed and evaluated to select…
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Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to…
Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble…
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Comparative bioavailability study following a single dose intravenous and buccal administration of…
As remdesivir, the first FDA-approved drug for SARS-CoV-2 infection, can be used only for hospitalized patients due to intravenous administration, there is an urgent need of effective oral antiviral formulations to be used at early stage of infection in an outpatient setting. The present paper…
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