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Bioavailability enhancement
Dabigatran Formulation for Oral Administration – an Evaluation
Dabigatran etexilate mesylate is a pro-drug of Dabigatran – a BSC Class II drug used as anti-coagulant in deep vein thrombosis as a direct thrombin inhibitor. Due to increasing solubility in the acidic regime, tartaric acid pellets (TAP) are used as starter beads. A processed formulation is compared…
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In Vitro and In Vivo Evaluations of Berberine-Loaded Microparticles Filled In-House 3D Printed…
The low oral bioavailability, short biological half-life, high dose, and frequent dosing of berberine (BBR) contribute to its restricted clinical use despite its extensive pharmacological activity. Thus, the objective of this study was to formulate sustained-release microparticles (MPs) using a…
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Enhanced circulation longevity and pharmacodynamics of metformin from surface-modified…
Metformin hydrochloride (MTH) has been associated with poor/incomplete absorption (50–60%), low bioavailability, short half-life (0.4–0.5 h), high dosage and dose-related side effects. To overcome these barriers and improve oral bioavailability and efficacy of MTH, surface-modified nanostructured…
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Development of self-microemulsifying tablets containing dutasteride for enhanced dissolution and…
This study aimed to develop self-microemulsifying tablets containing the hydrophobic drug dutasteride for easy administration and high in vivo absorption. The candidate lipids and surfactants were formulated into a self-microemulsifying drug delivery system (SMEDDS), and their mean droplet size upon…
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Pulsatile Delivery System for Antihypertensive Drug
The purpose of present work was to formulate an oral pulsatile drug delivery system to achieve time release of felodipine, based on chronopharmaceutical approach for the treatment of hypertension. System was prepared in the form of two layered tablets by press coating method. Active rapid release…
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The Value of Bead Coating in the Manufacturing of Amorphous Solid Dispersions: A Comparative…
Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers potential advantages regarding the minimization of physical stability issues, there is still a lack of in-depth understanding of the bead coating process and its value in relation to spray drying. Therefore,…
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Evonik launches new EUDRATEC® technology to improve solubility of oral small molecules
Essen, Germany. Evonik now offers EUDRATEC® SoluFlow, a new microparticle technology to enhance solubility of active pharmaceutical ingredients in oral drug products. This emulsion-based process technology overcomes solubility hurdles that cannot be resolved by existing manufacturing technologies.…
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Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties
To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@RLPO)…
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Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes. However, there are a series of formidable…
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Vehicles for Drug Administration to Children: Results and Learnings from an In-Depth Screening of…
Purpose
Mixing with liquids or soft foods is a common procedure to improve acceptability of oral medicines in children but may affect drug stability and the in vivo performance of the administered drug product. The aim of the present study was to obtain an overview of the variability of critical…
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