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Bioavailability enhancement
Apinovex™ Polymers – Solubility-Enhancing Excipients for Amorphous Solid Dispersions
Lubrizol’s Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray-dried amorphous solid dispersions (ASDs).
Apinovex polymers enable formulators to enhance the solubility of BCS Class II and IV APIs and…
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Nanocrystals based pulmonary inhalation delivery system: advance and challenge
Pulmonary inhalation administration is an ideal approach to locally treat lung disease and to achieve systemic administration for other diseases. However, the complex nature of the structural characteristics of the lungs often results in the difficulty in the development of lung inhalation…
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Bilayer Buccal Tablets of Furosemide: Design and Evaluation
Aim: In the present study, mucoadhesive bilayer buccal tablets of furosemide were fabricated with the objective of avoiding first-pass metabolism and enhancing the bioavailability along with reducing the dosing frequency.
Methodology: Direct compression method was used to prepare bilayer buccal…
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Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks…
Polymeric micelles (PMs) have been explored pre-clinically for the delivery of chemotherapeutics to treat cancer. Their unique features, such as easy surface functionalization, stimuli-responsiveness, good stability, ability to modify drug release, enhanced permeation and retention effect, and…
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Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using…
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary amorphous solid dispersions (SDs) of Coenzyme Q10 (CoQ10), a biopharmaceutics classification system (BCS) II compound and Soluplus® were prepared to…
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Pharmatrans specific functional starter cores for improved bioavailability and dissolution
Pharmatrans Sanaq specialized range of pharmaceutical excipients and novel drug vehicles includes pellets to aid design of various types of solid dosage forms.
The range has been extended from standard types of microcrystalline cellulose, such as neutral starter cores CELLETS®, purely made of…
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Solubility enhancement – Transform insoluble drugs into stable and efficient formulations
Recent industry trends show many pharmaceutical manufacturers are creating drugs with greater degrees of lipophilicity, higher molecular weight, greater physical form complexity and lower aqueous solubility. Unfortunately, these characteristics often produce poorly soluble drugs, which means the…
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Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal…
Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a successful alternative for the existing oral…
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Formulating for the Future: Oral Drug Delivery for Improving Bioavailability & Patient Outcomes
Oral drug administration is critical for the delivery of drugs in various therapeutic areas, such as cardiovascular and pain management. It is considered the preferred route of administration due to its significant advantages, including being both painless and convenient. The importance of oral drug…
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Nanostructured Lipid Carrier: A Potential System for Enhanced Oral Bioavailability of Felodipine
Background: Felodipine is BCS class II drug with poor and variable bioavailability due to its insolubility in water (19mg/L) and extensive metabolism in liver and gut. Thus, in the study Nanostructured lipid carriers (NLCs) of Felodipine were formulated to improve its solubility and bioavailability.…
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