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Bioavailability enhancement
Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to…
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Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance solubility, dissolution, and bioavailability via spray drying technology. At the same time, we hope to develop a more convenient in vitromethod to predict…
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Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain…
Rivastigmine, a reversible cholinesterase inhibitor, is frequently indicated in the management of demented conditions associated with Alzheimer disease. The major hurdle of delivering this drug through the oral route is its poor bioavailability, which prompted the development of novel delivery…
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Emulgel Approach to Formulation Development: A Review
Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The…
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Development and Pharmacokinetic Evaluation of a Self-Nanoemulsifying Drug Delivery System for the…
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased in recent years. These drugs often possess physicochemical properties that result in poor oral bioavailability, and their clinical potential may be limited without adequate formulation strategies.…
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Development of Fully Redispersible Dried Nanocrystals by Using Sucrose Laurate as Stabilizer for…
There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous suspensions, and once the suspensions are dried for development of…
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Development of Self-Microemulsifying Drug Delivery System to Improve Nisoldipine Bioavailability:…
The authors attempted to fabricate a novel lipid-based formulation of a lipophilic drug, nisoldipine (NISO). As NISO belongs to BCS class 2 drug, it suffers from low bioavailability (5%). Hence, the research was intended to ameliorate oral bioavailability of NISO via intestinal lymphatic transport.…
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Lymphatic transport system to circumvent hepatic metabolism for oral delivery of lipid-based…
The oral route of administration for lipid-based nanocarriers is of immense importance for the drugs having low bioavailability because of extensive first-pass metabolism. These drug delivery systems have reportedly improved oral bioavailability via lymphatic transport. The solubility issues of a…
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Formulation and In Vivo Evaluation of a Solid Self-Emulsifying Drug Delivery System Using Oily…
Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly water-soluble drugs. Solid self-emulsifying drug delivery systems (s-SEDDS) offer several advantages including improved drug stability, ease of administration, and production. Most compounds employed in…
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Efficient Development of Sorafenib Tablets with Improved Oral Bioavailability Enabled by…
An amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation, was used to develop an immediate release tablet with improved oral bioavailability. An ASD of 40% drug loading with HPMC-AS (M grade), which exhibited…
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