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Bioavailability enhancement
How to Tame Recalcitrant Ingredients with Technological Processes
Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing for years. The spice is not only in demand in the culinary world, but has also found great promise in both consumer and scientific applications.1 …
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Gelucire® 59/14, solid surfactant for oral bioavailability enhancement
Gattefossé widens its range of functional excipients for oral bioavailability enhancement with a new grade of Gelucire®: Gelucire® 59/14, a mixture of lauroyl PEG-32 glycerides EP/NF and PEG 6000 EP/NF.
Gelucire® 59/14 is a self-emulsifying excipient used for oral bioavailability enhancement of…
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Nanotechnology Innovations to Enhance the Therapeutic Efficacy of Quercetin
Quercetin is a flavonol present in many vegetables and fruits. Generally, quercetin can be found in aglycone and glycoside forms, mainly in leaves. The absorption of this compound occurs in the large and small intestine, where it suffers glucuronidation, sulfidation, and methylation to improve…
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Boost your drug bioavailability with Labrafac™ MC60
Gattefossé widens its range of high quality, functional excipients for oral bioavailability enhancement with Labrafac™ MC60, glycerol monocaprylocaprate. Labrafac™ MC60 is used for oral bioavailability enhancement of poorly water-soluble, poorly permeable drugs.
Glycerol monocaprylocaprate is a…
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Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine
The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the oral bioavailability in rats. Based on the solubility determination and pseudo-ternary phase diagram, isopropyl palmitate (IPP) was chosen as the oil phase. Meanwhile,…
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Lipopolysaccharide Nanosystems for the Enhancement of Oral Bioavailability
Nanosystems that incorporate both polymers and lipids have garnered attention as emerging nanotechnology approach for oral drug delivery. These hybrid systems leverage on the combined properties of polymeric and lipid-based nanocarriers while eliminating their inherent limitations. In view of the…
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Rectal bioavailability of amoxicillin sodium in rabbits: Effects of suppository base and drug dose
In this paper, rectal absorption and tissue tolerance of amoxicillin sodium (AS) suppositories prepared in a hydrophilic base, polyethylene glycol (PEG) or lipophilic base, Suppocire® NA 15 (SNA 15), were investigated. Following in vitro characterization, including drug distribution in the…
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Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and…
Vancomycin (VCM) is a drug of choice for treating infections caused by Staphylococcus species, reported being the most causative agent of bacterial endophthalmitis. However, the ocular bioavailability of topically applied VCM is low due to its high molecular weight and hydrophilicity. The current…
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Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of…
The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the hypoglycemic activity of the active metabolites of the extract. The…
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Resveratrol Loaded Cubic Phase Nanoparticles with Enhanced Oral Bioavailability
Resveratrol (RES), a naturally occurring hydrophobic polyphenolic compound, has shown potential anticancer activity. However, due to low aqueous solubility and extensive first pass metabolism (primarily by cytochrome enzymes), it shows poor oral bioavailability. In the present work, novel RES loaded…
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