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Bioavailability enhancement
Inhalable bedaquiline-loaded cubosomes for the treatment of non-small cell lung cancer (NSCLC)
Highlights
• Bedaquiline-loaded cubosomes (BQLC) displayed excellent particle size, zeta potential, and aerosolization behavior suitable for NSCLC treatment.
• BQLCs were efficiently internalized by lung cancer cells and decreased IC50 by 3-fold compared to free bedaquiline.
• BQLCs…
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Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
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Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of…
Background: The purpose of this study was to screen various drug delivery systems for improving the aqueous solubility and oral bioavailability of sildenafil. Three representative techniques, solid self-nanoemulsifying drug delivery systems (SNEDDS), amorphous microspheres and crystalline…
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Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between…
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD), which convert a crystalline drug into an…
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N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic…
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields. In this study, TMC was used as a mucoadhesive adjuvant to enhance the oral bioavailability and hence antitumor effects of gemcitabine…
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Bioavailability enhancement of nanostructured microparticles of carvedilol
A high throughput encapsulation technique termed as electrospraying assisted by pressurized gas technology (EAPG) was used to produce nano-within-micro structures of a Biopharmaceutics Classification System (BCS) Class II model drug. Carvedilol is a lipid soluble compound, poorly absorbed in the…
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In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion…
Amorphous solid dispersion (ASD) dosage forms can improve the oral bioavailability of poorly water-soluble drugs, enabling the commercialization of new chemical entities and improving the efficacy and patient compliance of existing drugs. However, the development of robust, high-performing ASD…
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Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study
Oral cannabidiol (CBD) is approved by the Food and Drug Administration (FDA) to treat patients with Dravet and Lennox-Gastaut syndromes, and tuberous sclerosis complex. The therapeutic potential of oral CBD formulations is limited by extensive first-pass hepatic metabolism. Following oral…
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What Are the Important Factors That Influence API Crystallization in Miscible Amorphous…
In this perspective, the authors examine the various factors that should be considered when attempting to use miscible amorphous API–excipient mixtures (amorphous solid dispersions and coamorphous systems) to prevent the solid-state crystallization of API molecules when isothermally stored for long…
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Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug…
Among many methods to mitigate the solubility limitations of drug compounds, amorphous solid dispersion (ASD) is considered to be one of the most promising strategies to enhance the dissolution and bioavailability of poorly water-soluble drugs. The enhancement of ASD in the oral absorption of drugs…
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