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Bioavailability enhancement
Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous…
The bioavailability of insoluble crystalline active pharmaceutical ingredients (APIs) can be enhanced by formulation as amorphous solid dispersions (ASDs). One of the key factors of ASD stabilization is the formation of drug–polymer interactions at the molecular level. Here, we used a range of…
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Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in…
Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the oral delivery of poorly water-soluble drugs. However, failure to maintain adequate aqueous solubility after coming into contact with gastrointestinal fluids is a major drawback.
In…
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Formulation and Characterization of Eplerenone Mucoadhesive Buccal Tablets
Mucoadhesive drug release system is a preferably unidirectional release system where mucosal epithelial exterior is enclosed by the mucus deposit that interacts with the bio-adhesive drug delivery system and swelling time of the buccal dosage form which is amplified by mucin molecules at the…
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Enhanced Bioavailability of AC1497, a Novel Anticancer Drug Candidate, via a Self-Nanoemulsifying…
AC1497 is an effective dual inhibitor of malate dehydrogenase 1 and 2 targeting cancer metabolism. However, its poor aqueous solubility results in low bioavailability, limiting its clinical development. This study was conducted to develop an effective self-nanoemulsifying drug delivery system…
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Hybrid polylactic acid/Eudragit L100 nanoparticles: A promising system for enhancement of…
Luteolin is a valuable natural drug for the treatment of oxidative stress associated diseases, but its use is hindered by gastric instability and poor bioavailability. Given that hybrid polymeric nanoparticles may have potential applications in the design of oral drug delivery systems, this study…
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Self-Assembling Dioscorea bulbifera loaded mixed micelles: Formulation optimization, in-vitro…
Dioscorea bulbifera (DB)is one among the traditionally used medicinal plant which has been reported to have anticancer property and capable of inducing apoptosis of tumors, but the poor water solubility restricts its pharmacological application. The study aims at improving the aqueous solubility of …
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Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for…
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors, including small molecule drugs, natural constituents, and…
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Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film
Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study, microcontainers with a diameter of 300 µm and a height of 100 µm,…
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New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug…
The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel dexibuprofen-loaded solid SNEDDS was composed of dexibuprofen,…
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Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug…
We seek to further address the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased bioavailability are not compromised. To address…
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