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Bioavailability enhancement
Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to…
Background
Nutraceuticals often referred as medicinally or nutritionally functional foods has drawn extensive attention in recent years because of their wide array of pharmacological activities. It has been well established that the consumption of nutraceuticals is consistently linked with…
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Structured edible lipid-based particle systems for oral drug-delivery
Oral administration is the most popular and patient-compliant route for drug delivery, though it raises great challenges due to the involvement of the gastro-intestine (GI) system and the drug bioavailability. Drug bioavailability is directly related to its ability to dissolve, transport and/or…
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Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant
The emergence of multidrug resistance (MDR) in malignant tumors is the primary reason for invalid chemotherapy. Antitumor drugs are often adversely affected by the MDR of tumor cells. Treatments using conventional drugs, which have specific drug targets, hardly regulate the complex signaling pathway…
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Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a…
Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester prodrug fosphenytoin is soluble, although less permeable. In a previous study, the intranasal administration of aqueous-based formulations of fosphenytoin led to high but delayed phenytoin bioavailability compared to…
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Formulation of Chewable Tablets Containing Carbamazepine-β-cyclodextrin Inclusion Complex and F-Melt…
Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect. Lots of methods have been devised to improve its solubility, the large number of proposed solutions being a sign that…
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Solubility Enhancement of Diclofenac Using Solid Dispersions
The phenomenon which gives rise to a homogenous system, formed by the dissolution of solute in a solvent is known as solubility. Low solubility is the limiting factor in formulation development. Diclofenac being BCS class II drug have low aqueous solubility of 0.00401mg/ml. Amongst various…
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Hot-Melt Extrusion: a Roadmap for Product Development
Hot-melt extrusion has found extensive application as a feasible pharmaceutical technological option over recent years. HME applications include solubility enhancement, taste masking, and sustained drug release. As bioavailability enhancement is a hot topic of today’s science, one of the main…
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Polymer-mediated drug supersaturation – a spotlight on the interplay between phase-separated…
Hypothesis
Colloidal aggregation phenomena have been found responsible for the supersaturation of poorly water-soluble drugs, potentially leading to bioavailability enhancements. Unlike coarse precipitates, phase separation in the form of colloids, is expected to enhance drug supersaturation…
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Development of Gelucire® 48/16 and TPGS Mixed Micelles and Its Pellet Formulation by Extrusion…
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes formulation of curcumin-loaded mixed micelles of Gelucire® 48/16 and TPGS for its dissolution rate enhancement. Curcumin was dispersed in these molten…
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Development and evaluation of a composite dosage form containing desmopressin acetate for buccal…
Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and oromucosal, whereby nasal administration results in high…
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