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Bioavailability enhancement
Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel…
The objective of this study was to fabricate a novel drug delivery system using Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer) and glycyrrhizic acid to improve solubility, bioavailability, and anti-hyperuricemic activity of aloe emodin (AE). The AE-loaded…
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Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions
The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release of the drug.
Methods: The nateglinide SD prepared using crospovidone and evaluated for drug content and drug dissolution. The optimized…
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Formulate and Evaluate Famciclovir Floating Tablets
Floating drug delivery system of famciclovir was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability by using different polymers like HPMC E15, Xanthan gum, methyl cellulose and compritol 888 ATO with different concentration. Famciclovir capable of…
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Design and characterisation of an amorphous formulation of nifedipine for the treatment of autonomic…
Current treatment for autonomic dysreflexia (AD) involves rupturing a liquid-filled soft capsule of nifedipine to aid rapid drug release and absorption, however, this application is not covered under the manufacturer's license. The objective of the current work was to design a rapidly dissolving…
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Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile…
Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed…
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Development of poly-L-lysine multi-functionalized muco-penetrating self- emulsifying drug delivery…
Salmonella typhi infections are difficult to treat due to poor penetration of current antibiotic ciprofloxacin (CIP)modalities into the intracellular compartments of macrophages owing to poor solubilization and oral bioavailability. Poor penetration and dissolution of CIP lead to development of…
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Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with…
Salidroside (SAL) is a phenolic substance with high solubility and low permeability, which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora, resulting in lower bioavailability. The aim of this study was to develop and optimize a water-in-oil nanoemulsion…
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Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment
Peptic ulcer disease (PUD) is a common condition that is induced by acid and pepsin causing lesions in the mucosa of the duodenum and stomach. The pathogenesis of PUD is a many-sided scenario, which involves an imbalance between protective factors, such as prostaglandins, blood flow, and cell…
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Supersaturable self-microemulsifying delivery systems: an approach to enhance oral bioavailability…
This study explored the design of supersaturable self-microemulsifying drug delivery systems (S-SMEDDS) to address poor solubility and oral bioavailability of a novel benzimidazole derivative anticancer drug (BI). Firstly, self-microemulsifying drug delivery systems SMEDDS made of Miglyol® 812,…
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Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid…
Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes the pharmacological and therapeutic activity of drug to the…
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