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Bioavailability enhancement
Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in…
Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights in this matter, we conducted a randomized cross-over design…
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Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing…
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer…
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Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of…
Innovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a fusion-emulsification method, to increase skin permeation and in vivo…
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Oral Insulin Delivery by Chitosan Coated Solid Lipid Nanoparticles: ex vivo and in vivo Studies
The objective of this investigation was to formulate chitosan coated, insulin-loaded solid lipid nanoparticles (SLN) for oral administration and investigate their potential as an effective alternative to the subcutaneous injection.
Methods: The SLN were prepared from glyceryl monostearate and…
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Predicting process design spaces for spray drying amorphous solid dispersions
Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying processes. The product quality can be decisively influenced by the choice of process parameters. Following the quality-by-design approach, the identification of the spray-drying process design space is thus an integral…
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Effect of Carrier Type and Tween® 80 Concentration on the Release of Silymarin from Amorphous Solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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Lipid excipients to unlock oral bioavailability issues
Many active pharmaceutical ingredients have poor water-solubility and/or low permeability, leading to bioavailability issues. Lipid-based formulation (LBF) is a well-known strategy to overcome these hurdles and increase in vivo drug exposure. Depending on their composition, LBF exhibit different in…
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Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability…
Meclizine shows poor oral bioavailability and slow onset of action due to its low water solubility and poor permeability. In the present study, meclizine-loaded nanostructured lipid carriers (NLCs) were developed to improve oral bioavailability of meclizine. NLCs were prepared using Gelucire…
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A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the…
Fenofibrate is an effective lipid-lowering drug; however, its poor solubility and high log p (5.2) result in insufficient absorption from the gastrointestinal tract, leading to poor bioavailability. In this study, a one-step continuous twin-screw melt granulation process was investigated to improve…
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