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Bioavailability enhancement
Enabling Oral Amphotericin B Delivery by Merging the Benefits of Prodrug Approach and…
Amphotericin B (AmB) is gold standard therapy for leishmaniasis and fungal infections. Considering the global disease burden, nearly 90% of cases occur in economically vulnerable countries, making the cost of AmB therapy a critical healthcare challenge in controlling disease burden. All currently…
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Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral…
Purpose: To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed.
Methods: Surfactants and solid carriers were screened based on a solubility and a flowability test, respectively. Supersaturating agents, including Poloxamer 407 (P407),…
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In-vitro/In-vivo Evaluation of Paclitaxel Freeze-Dried Micellar Nanoparticles Intended for Buccal…
Biopharmaceutics Classified drugs in the category II, III and IV encounter many challenges during development of buccal formulations with adequate bioavailability. This study took the advantage of nanoparticles based on permeability enhancers (PEs) to develop novel paclitaxel (PX) nanoparticles…
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Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of…
Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble drugs, where the maintenance of supersaturation plays a key role in enhancing the absorption process. However, quantitative prediction of oral absorption from…
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A novel combination of Soluplus ®/Poloxamer for Meloxicam solid dispersions via hot melt extrusion…
Objective: Bioavailability of Meloxicam (MLX) from solid dispersions (SDs), against innovator product Mobic® in humans was conducted. Furthermore, to establish a good in vitro-in vivocorrelation (IVIVC); dissolution studies were carried-out in different media.
Methods: MLX/SDs was prepared using…
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A novel combination of Soluplus® and Poloxamer for Meloxicam solid dispersions via hot melt…
The hot melt extrusion (HME) technique was proposed to prepare solid dispersions (SDs) of the high melting point meloxicam (MLX) for the first time. Extruded MLX/SDs (EXT) prepared by HME were compared with fusion (FUS) and physical mixture (PM) using different ratios of Soluplus® (SOL) to Poloxamer…
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Self-Emulsifying Drug Delivery System: A Novel Approach for Oral Delivery of Poorly Water Soluble…
Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such systems considered one of the most favorable and efficient approaches to enhance solubility, increase drug absorption and hence, enhance its oral bioavailability of poorly water soluble…
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Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The…
We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry method was used to produce the amorphous salt of CFZ with poly(acrylic acid) (PAA) at 75 wt % drug loading.…
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Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached…
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and…
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Preparation, characterization and in vivo pharmacokinetic evaluation of curcuminoids-loaded solid…
Curcuminoids are considered as one of the most promising phytochemicals with numerous pharmacological effects and therapeutic potentials. Nevertheless, their inappropriate pharmacokinetic properties (i.e., poor bioavailability) have made pharmaceutical industries face many challenges in developing…
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