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Bioavailability enhancement
3D-printed tablets using a single-step hot-melt pneumatic process for poorly soluble drugs
Main purpose was to evaluate the applicability of a 3D-printer equipped with a hot-melt pneumatic dispenser as a single-step process to prepare tablet dosage forms. Dutasteride, a poorly water-soluble drug, was selected as a model drug. Soluplus®, Kollidon® VA 64, Eudragit® E PO, and hydroxypropyl…
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How Does the Addition of Kollidon®VA64 Inhibit the Recrystallization and Improve Ezetimibe…
Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many drug compounds. However, in many formulations the content of polymeric stabilizer is high, which is undesirable from the perspective of future applications. Thus, studying the composition-dependent…
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Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral…
Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms. Resveratrol solubility high-throughput screening with different carriers was performed showing an enhancement above…
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Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly…
Many new chemical entities have limited water solubility and therefore show low and/or variable oral bioavailability. Among the various strategies to overcome this challenge, nanoformulations have emerged as an attractive strategy to improve the oral permeability and absorption of many hydrophobic…
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Phytophospholipid Complex of Caffeic Acid: Development, In vitro Characterization, and In Vivo…
Caffeic acid (CA), a hydroxycinnamic acid possessing a variety of pharmacological activities, has caused a growing interest for the treatment of hyperlipidemia and associated conditions. This work endeavored to develop a novel formulation of CA-Phospholipon® 90H complex (CA-PC) using a solvent…
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Impact of binary/ternary solid dispersion Utilizing poloxamer 188 and TPGS to improve pharmaceutical…
Bedaquiline fumarate (BDQN) is approved in year 2012 to treat multidrug resistance tuberculosis (MDR-TB) through accelerated approval pathway by FDA. It belongs to class II of biopharmaceutical classification system (BCS) and shows poor aqueous solubility and dissolution rate which eventually leads…
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Preparation and Evaluation of Glaucocalyxin A Sustained- Release Pellets Based on Phospholipid…
Objective: Glaucocalyxin A (GLA) suffers from low oral bioavailability and rapid in vivo metabolism. Therefore, the purpose of this study was to develop a new formulation to enhance the oral bioavailability simultaneously sustained release of GLA.
Material and methods: GLA-phospholipid complex…
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Enhanced oral bioavailability of nintedanib esylate with nanostructured lipid carriers by lymphatic…
The present research work was aimed to explore the ability of nanostructured lipid carriers (NLCs) to improve oral bioavailability of Nintedanib esylate (NE) via lymphatic uptake. The NE loaded NLCs (NE-NLCs) were fabricated using high speed homogenization followed by probe sonication method and…
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Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement…
This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique.
NSC…
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Tinctures or oily solutions
Tinctures, as oily solutions, are an ancient mode of preparation of plant extracts, but are still very actual and attractive, especially for cannabinoid formulations. With a straightforward development, they can easily be developed. They are also very convenient for the patients who can take a few…
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